2nyz

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[[Image:2nyz.jpg|left|200px]]<br /><applet load="2nyz" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2nyz, resolution 2.60&Aring;" />
 
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'''Viral Chemokine Binding Protein M3 From Murine Gammaherpesvirus68 In Complex With The C- Chemokine XCL1'''<br />
 
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==Overview==
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==Viral Chemokine Binding Protein M3 From Murine Gammaherpesvirus68 In Complex With The C- Chemokine XCL1==
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Viruses have evolved a myriad of evasion strategies focused on undermining, chemokine-mediated immune surveillance, exemplified by the mouse, gamma-herpesvirus 68 M3 decoy receptor. Crystal structures of M3 in, complex with C chemokine ligand 1/lymphotactin and CC chemokine ligand, 2/monocyte chemoattractant protein 1 reveal that invariant chemokine, features associated with G protein-coupled receptor binding are primarily, recognized by the decoy C-terminal domain, whereas the N-terminal domain, (NTD) reconfigures to engage divergent basic residue clusters on the, surface of chemokines. Favorable electrostatic forces dramatically enhance, the association kinetics of chemokine binding by M3, with a primary role, ascribed to acidic NTD regions that effectively mimic glycosaminoglycan, interactions. Thus, M3 employs two distinct mechanisms of chemical, imitation to potently sequester chemokines, thereby inhibiting chemokine, receptor binding events as well as the formation of chemotactic gradients, necessary for directed leukocyte trafficking.
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<StructureSection load='2nyz' size='340' side='right'caption='[[2nyz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2nyz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Murid_gammaherpesvirus_4 Murid gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NYZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nyz OCA], [https://pdbe.org/2nyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nyz RCSB], [https://www.ebi.ac.uk/pdbsum/2nyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nyz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O41925_MHV68 O41925_MHV68]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/2nyz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nyz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Viruses have evolved a myriad of evasion strategies focused on undermining chemokine-mediated immune surveillance, exemplified by the mouse gamma-herpesvirus 68 M3 decoy receptor. Crystal structures of M3 in complex with C chemokine ligand 1/lymphotactin and CC chemokine ligand 2/monocyte chemoattractant protein 1 reveal that invariant chemokine features associated with G protein-coupled receptor binding are primarily recognized by the decoy C-terminal domain, whereas the N-terminal domain (NTD) reconfigures to engage divergent basic residue clusters on the surface of chemokines. Favorable electrostatic forces dramatically enhance the association kinetics of chemokine binding by M3, with a primary role ascribed to acidic NTD regions that effectively mimic glycosaminoglycan interactions. Thus, M3 employs two distinct mechanisms of chemical imitation to potently sequester chemokines, thereby inhibiting chemokine receptor binding events as well as the formation of chemotactic gradients necessary for directed leukocyte trafficking.
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==About this Structure==
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Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor.,Alexander-Brett JM, Fremont DH J Exp Med. 2007 Dec 24;204(13):3157-72. Epub 2007 Dec 10. PMID:18070938<ref>PMID:18070938</ref>
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2NYZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NYZ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor., Alexander-Brett JM, Fremont DH, J Exp Med. 2007 Dec 24;204(13):3157-72. Epub 2007 Dec 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18070938 18070938]
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</div>
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[[Category: Murid herpesvirus 1]]
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<div class="pdbe-citations 2nyz" style="background-color:#fffaf0;"></div>
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[[Category: Protein complex]]
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== References ==
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[[Category: Alexander-Brett, J.M.]]
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<references/>
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[[Category: Fremont, D.H.]]
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__TOC__
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[[Category: chemokine]]
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</StructureSection>
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[[Category: protein-protein complex]]
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[[Category: Homo sapiens]]
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[[Category: viral decoy receptor]]
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[[Category: Large Structures]]
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[[Category: viral protein/cytokine complex]]
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[[Category: Murid gammaherpesvirus 4]]
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[[Category: Alexander-Brett JM]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 13 08:17:42 2008''
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[[Category: Fremont DH]]

Current revision

Viral Chemokine Binding Protein M3 From Murine Gammaherpesvirus68 In Complex With The C- Chemokine XCL1

PDB ID 2nyz

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