2lfh

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[[Image:2lfh.png|left|200px]]
 
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==Solution NMR Structure of the Helix-loop-Helix Domain of Human ID3 Protein, Northeast Structural Genomics Consortium Target HR3111A==
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The line below this paragraph, containing "STRUCTURE_2lfh", creates the "Structure Box" on the page.
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<StructureSection load='2lfh' size='340' side='right'caption='[[2lfh]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lfh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LFH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lfh OCA], [https://pdbe.org/2lfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lfh RCSB], [https://www.ebi.ac.uk/pdbsum/2lfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lfh ProSAT]</span></td></tr>
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{{STRUCTURE_2lfh| PDB=2lfh | SCENE= }}
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</table>
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== Function ==
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===Solution NMR Structure of the Helix-loop-Helix Domain of Human ID3 Protein, Northeast Structural Genomics Consortium Target HR3111A===
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[https://www.uniprot.org/uniprot/ID3_HUMAN ID3_HUMAN] ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors.<ref>PMID:8437843</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2lfh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFH OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Eletsky, A.]]
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[[Category: Acton TB]]
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[[Category: Everett, J K.]]
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[[Category: Eletsky A]]
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[[Category: Janjua, H.]]
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[[Category: Everett JK]]
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[[Category: Kohan, E.]]
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[[Category: Janjua H]]
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[[Category: Montelione, G T.]]
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[[Category: Kohan E]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Szyperski, T.]]
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[[Category: Szyperski T]]
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[[Category: Wang, D.]]
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[[Category: Wang D]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Dna binding protein inhibitor]]
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[[Category: Helix-loop-helix]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Solution NMR Structure of the Helix-loop-Helix Domain of Human ID3 Protein, Northeast Structural Genomics Consortium Target HR3111A

PDB ID 2lfh

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