3vib

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'''Unreleased structure'''
 
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The entry 3vib is ON HOLD until Paper Publication
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==Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae==
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<StructureSection load='3vib' size='340' side='right'caption='[[3vib]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Kumaraswami, M., Shafer, W.M., Brennan, R.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vib]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VIB FirstGlance]. <br>
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Description: Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vib OCA], [https://pdbe.org/3vib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vib RCSB], [https://www.ebi.ac.uk/pdbsum/3vib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vib ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTRR_NEIGO MTRR_NEIGO] Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents (PubMed:8196548). Represses transcription of the mtrCDE-encoded efflux pump by binding within the mtrCDE promoter (PubMed:9209024, PubMed:23221802). Also negatively regulates the expression of farR, by binding to its promoter region, leading indirectly to the positive regulation of expression of the farAB-encoded efflux pump (PubMed:14645274).<ref>PMID:14645274</ref> <ref>PMID:23221802</ref> <ref>PMID:8196548</ref> <ref>PMID:9209024</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Neisseria gonorrhoeae]]
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[[Category: Brennan RG]]
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[[Category: Kumaraswami M]]
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[[Category: Shafer WM]]

Current revision

Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae

PDB ID 3vib

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