4ajm
From Proteopedia
(Difference between revisions)
m (Protected "4ajm" [edit=sysop:move=sysop]) |
|||
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors== | |
| + | <StructureSection load='4ajm' size='340' side='right'caption='[[4ajm]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ajm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AJM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3A6:3-AMINO-6-FLUORO-2-[4-(2-METHYLPYRIDIN-4-YL)PHENYL]-N-(METHYLSULFONYL)QUINOLINE-4-CARBOXAMIDE'>3A6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ajm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajm OCA], [https://pdbe.org/4ajm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ajm RCSB], [https://www.ebi.ac.uk/pdbsum/4ajm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aharony D]] | ||
| + | [[Category: Akerud T]] | ||
| + | [[Category: Albert JS]] | ||
| + | [[Category: Back E]] | ||
| + | [[Category: Geschwindner S]] | ||
| + | [[Category: Hillertz P]] | ||
| + | [[Category: Horsefeld R]] | ||
| + | [[Category: Johansson P]] | ||
| + | [[Category: Scott C]] | ||
| + | [[Category: Spadola L]] | ||
| + | [[Category: Spear N]] | ||
| + | [[Category: Tian G]] | ||
| + | [[Category: Tigerstrom A]] | ||
Current revision
Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors
| |||||||||||
Categories: Homo sapiens | Large Structures | Aharony D | Akerud T | Albert JS | Back E | Geschwindner S | Hillertz P | Horsefeld R | Johansson P | Scott C | Spadola L | Spear N | Tian G | Tigerstrom A
