2lk3

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[[Image:2lk3.jpg|left|200px]]
 
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==U2/U6 Helix I==
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The line below this paragraph, containing "STRUCTURE_2lk3", creates the "Structure Box" on the page.
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<StructureSection load='2lk3' size='340' side='right'caption='[[2lk3]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LK3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lk3 OCA], [https://pdbe.org/2lk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lk3 RCSB], [https://www.ebi.ac.uk/pdbsum/2lk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lk3 ProSAT]</span></td></tr>
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{{STRUCTURE_2lk3| PDB=2lk3 | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The U2/U6 snRNA complex is a conserved and essential component of the active spliceosome that interacts with the pre-mRNA substrate and essential protein splicing factors to promote splicing catalysis. Here we have elucidated the solution structure of a 111-nucleotide U2/U6 complex using an approach that integrates SAXS, NMR, and molecular modeling. The U2/U6 structure contains a three-helix junction that forms an extended "Y" shape. The U6 internal stem-loop (ISL) forms a continuous stack with U2/U6 Helices Ib, Ia, and III. The coaxial stacking of Helix Ib on the U6 ISL is a configuration that is similar to the Domain V structure in group II introns. Interestingly, essential features of the complex-including the U80 metal binding site, AGC triad, and pre-mRNA recognition sites-localize to one face of the molecule. This observation suggests that the U2/U6 structure is well-suited for orienting substrate and cofactors during splicing catalysis.
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===U2/U6 Helix I===
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Structure of the yeast U2/U6 snRNA complex.,Burke JE, Sashital DG, Zuo X, Wang YX, Butcher SE RNA. 2012 Feb 10. PMID:22328579<ref>PMID:22328579</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[2lk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LK3 OCA].
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<div class="pdbe-citations 2lk3" style="background-color:#fffaf0;"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022328579</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Burke, J E.]]
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[[Category: Burke JE]]
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[[Category: Butcher, S E.]]
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[[Category: Butcher SE]]
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[[Category: Sashital, D G.]]
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[[Category: Sashital DG]]
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[[Category: Wang, Y.]]
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[[Category: Wang Y]]
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[[Category: Zuo, X E.]]
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[[Category: Zuo XE]]
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[[Category: Bulge]]
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[[Category: Rna]]
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Current revision

U2/U6 Helix I

PDB ID 2lk3

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