3u6y

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[[Image:3u6y.jpg|left|200px]]
 
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==Crystal structure of ALBA2-DNA complex==
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The line below this paragraph, containing "STRUCTURE_3u6y", creates the "Structure Box" on the page.
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<StructureSection load='3u6y' size='340' side='right'caption='[[3u6y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3u6y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix_K1 Aeropyrum pernix K1] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U6Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3u6y| PDB=3u6y | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6y OCA], [https://pdbe.org/3u6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u6y RCSB], [https://www.ebi.ac.uk/pdbsum/3u6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALBA2_AERPE ALBA2_AERPE] Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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All thermophilic and hyperthermophilic archaea encode homologs of dimeric Alba (Sac10b) proteins that bind cooperatively at high density to DNA. Here, we report the 2.0 A resolution crystal structure of an Alba2 (Ape10b2)-dsDNA complex from Aeropyrum pernix K1. A rectangular tube-like structure encompassing duplex DNA reveals the positively charged residues in the monomer-monomer interface of each dimer packing on either side of the bound dsDNA in successive minor grooves. The extended hairpin loop connecting strands beta3 and beta4 undergoes significant conformational changes upon DNA binding to accommodate the other Alba2 dimer during oligomerization. Mutational analysis of key interacting residues confirmed the specificity of Alba2-dsDNA interactions.
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===Crystal structure of ALBA2-DNA complex===
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Crystal structure of archaeal chromatin protein Alba2-double-stranded DNA complex from Aeropyrum pernix K1.,Tanaka T, Padavattan S, Kumarevel T J Biol Chem. 2012 Mar 23;287(13):10394-402. Epub 2012 Feb 10. PMID:22334696<ref>PMID:22334696</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18004791}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3u6y" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18004791 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18004791}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Aeropyrum pernix K1]]
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[[3u6y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6Y OCA].
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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==Reference==
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[[Category: Kumarevel T]]
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<ref group="xtra">PMID:018004791</ref><references group="xtra"/>
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[[Category: Tanaka T]]
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[[Category: Aeropyrum pernix]]
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[[Category: Kumarevel, T.]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tanaka, T.]]
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[[Category: Alba 2]]
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[[Category: Archaea]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna-binding protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of ALBA2-DNA complex

PDB ID 3u6y

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