Gal3-Gal80-Gal4

<StructureSection load='1d66' size='350' side='right' caption='Yeast Gal4 complex with DNA and Zn+2 ions (wheat) (PDB entry [[1d66]])' scene=''>

'''Gal3-Gal80-Gal4''' proteins of yeast comprise a signal transducer that controls the galactose-inducible Gal4-mediated transcription activation of GAL regulon genes. '''Gal3''' and '''Gal4'''<ref>PMID:16670683</ref> are regulators of the rapid induction of the galactose system. In the absence of galactose Gal80<ref>PMID:15695361</ref> binds to Gal4 and prohibits it from activating transcription. In the presence of galactose, Gal3 binds to Gal80 to prohibit its inhibition of Gal4. For '''Gal4''' details see <br />[[User:Amir Mitchell/Gal4]]<br/ >[[User: Wayne Decatur/Gal 4]]<br />[[Evans Gal4]]<br />[[DNA-protein interactions]].

The Gal4 protein consists of a <scene name='48/483908/Dimer/2'>dimer</scene> of identical subunits.

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

{{#tree:id=OrganizedByTopic|openlevels=0|

**[[3v5r]] – yGal3 – yeast <br />

**[[3v2u]] – yGal3 + Gal80 + ATP + galactose <br />

*Gal4

**[[1aw6]] – yGal4 DNA-binding domain – yeast – NMR<br />

**[[1hbw]] - yGal4 dimerization domain – NMR<br />

**[[3coq]] - yGal4 DNA-binding and dimerization domains + DNA<br />

**[[1d66]] – yGal4 + DNA

**[[7uik]], [[7uio]] – yGal4 in mediator-PIC complex – Cryo EM

*Gal80

**[[2nvw]] – KlGal80 – ''Kluyveromyces lactis'' <br />

**[[3e1k]] – KlGal80 + lactose regulatory protein Lac9 peptide <br />

**[[3btu]], [[3btv]] – yGal80 (mutant) <br />

**[[3bts]] – yGal80 + Gal4 peptide + NAD <br />

}}

== References ==

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