3qo4

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[[Image:3qo4.png|left|200px]]
 
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==The Crystal Structure of Death Receptor 6==
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The line below this paragraph, containing "STRUCTURE_3qo4", creates the "Structure Box" on the page.
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<StructureSection load='3qo4' size='340' side='right'caption='[[3qo4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qo4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QO4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3qo4| PDB=3qo4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo4 OCA], [https://pdbe.org/3qo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qo4 RCSB], [https://www.ebi.ac.uk/pdbsum/3qo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Death receptors belong to the tumor necrosis factor receptor (TNFR) super family and are intimately involved in the signal transduction during apoptosis, stress response and cellular survival. Here we present the crystal structure of recombinantly expressed death receptor six (DR6), one family member that was recently shown to bind to the amyloid precursor protein (APP) and hence to be probably involved in the development of Alzheimer's disease. The extracellular cysteine rich region of DR6, the typical ligand binding region of all TNFRs, was refined to 2.2 A resolution and shows that its four constituting cysteine rich domains (CRDs) are arranged in a rod-like overall structure, which presents DR6-specific surface patches responsible for the exclusive recognition of its ligand(s). Based on the structural data, the general ligand binding modes of TNFRs and molecular modeling experiments we were able to elucidate structural features of the potential DR6-APP signaling complex.
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===The Crystal Structure of Death Receptor 6===
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The Crystal Structure of Death Receptor 6 (DR6): A Potential Receptor of the Amyloid Precursor Protein (APP).,Kuester M, Kemmerzehl S, Dahms SO, Roeser D, Than ME J Mol Biol. 2011 Jun 3;409(2):189-201. Epub 2011 Apr 2. PMID:21463639<ref>PMID:21463639</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qo4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21463639 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21463639}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3qo4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO4 OCA].
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==Reference==
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<ref group="xtra">PMID:021463639</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dahms, S O.]]
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[[Category: Large Structures]]
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[[Category: Kemmerzehl, S.]]
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[[Category: Dahms SO]]
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[[Category: Kuester, M.]]
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[[Category: Kemmerzehl S]]
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[[Category: Roeser, D.]]
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[[Category: Kuester M]]
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[[Category: Than, M E.]]
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[[Category: Roeser D]]
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[[Category: Alzheimer s disease]]
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[[Category: Than ME]]
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[[Category: Apoptosis]]
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[[Category: Ligand-receptor-recognition]]
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Current revision

The Crystal Structure of Death Receptor 6

PDB ID 3qo4

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