3pqi

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[[Image:3pqi.png|left|200px]]
 
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==Crystal structure of the bacteriophage phi92 membrane-piercing protein gp138==
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The line below this paragraph, containing "STRUCTURE_3pqi", creates the "Structure Box" on the page.
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<StructureSection load='3pqi' size='340' side='right'caption='[[3pqi]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pqi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteriophage_sp. Bacteriophage sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PQI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.642&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_3pqi| PDB=3pqi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pqi OCA], [https://pdbe.org/3pqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pqi RCSB], [https://www.ebi.ac.uk/pdbsum/3pqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pqi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/I7HXF9_9CAUD I7HXF9_9CAUD]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacteriophages with contractile tails and the bacterial type VI secretion system have been proposed to use a special protein to create an opening in the host cell membrane during infection. These proteins have a modular architecture but invariably contain an oligonucleotide/oligosaccharide-binding (OB-fold) domain and a long beta-helical C-terminal domain, which initiates the contact with the host cell membrane. Using X-ray crystallography and electron microscopy, we report the atomic structure of the membrane-piercing proteins from bacteriophages P2 and varphi92 and identify the residues that constitute the membrane-attacking apex. Both proteins form compact spikes with a approximately 10A diameter tip that is stabilized by a centrally positioned iron ion bound by six histidine residues. The accumulated data strongly suggest that, in the process of membrane penetration, the spikes are translocated through the lipid bilayer without undergoing major unfolding.
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===Crystal structure of the bacteriophage phi92 membrane-piercing protein gp138===
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Phage pierces the host cell membrane with the iron-loaded spike.,Browning C, Shneider MM, Bowman VD, Schwarzer D, Leiman PG Structure. 2012 Feb 8;20(2):326-39. PMID:22325780<ref>PMID:22325780</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22325780}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3pqi" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22325780 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22325780}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Bacteriophage sp]]
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[[3pqi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_phage_f237 Vibrio phage f237]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PQI OCA].
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[[Category: Large Structures]]
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[[Category: Browning C]]
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==Reference==
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[[Category: Leiman PG]]
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<ref group="xtra">PMID:022325780</ref><references group="xtra"/>
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[[Category: Shneider M]]
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[[Category: Vibrio phage f237]]
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[[Category: Browning, C.]]
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[[Category: Leiman, P G.]]
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[[Category: Shneider, M.]]
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[[Category: Beta-helix]]
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[[Category: Cell membrane piercing]]
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[[Category: Iron-binding]]
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[[Category: Ob-fold]]
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[[Category: Phage baseplate]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of the bacteriophage phi92 membrane-piercing protein gp138

PDB ID 3pqi

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