3leg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:35, 19 July 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3leg.png|left|200px]]
 
-
<!--
+
==Lectin Domain of Lectinolysin complexed with Lewis Y Antigen==
-
The line below this paragraph, containing "STRUCTURE_3leg", creates the "Structure Box" on the page.
+
<StructureSection load='3leg' size='340' side='right'caption='[[3leg]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3leg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LEG FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PRD_900054:Lewis+Y+antigen,+beta+anomer'>PRD_900054</scene></td></tr>
-
{{STRUCTURE_3leg| PDB=3leg | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3leg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3leg OCA], [https://pdbe.org/3leg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3leg RCSB], [https://www.ebi.ac.uk/pdbsum/3leg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3leg ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q2PHL4_STRMT Q2PHL4_STRMT]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The cholesterol-dependent cytolysins (CDCs) punch holes in target cell membranes through a highly regulated process. Streptococcus mitis lectinolysin (LLY) exhibits another layer of regulation with a lectin domain that enhances the pore-forming activity of the toxin. We have determined the crystal structures of the lectin domain by itself and in complex with various glycans that reveal the molecular basis for the Lewis antigen specificity of LLY. A small-angle X-ray scattering study of intact LLY reveals the molecule is flat and elongated with the lectin domain oriented so that the Lewis antigen-binding site is exposed. We suggest that the lectin domain enhances the pore-forming activity of LLY by concentrating toxin molecules at fucose-rich sites on membranes, thus promoting the formation of prepore oligomers on the surface of susceptible cells.
-
===Lectin Domain of Lectinolysin complexed with Lewis Y Antigen===
+
Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.,Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW Structure. 2012 Feb 8;20(2):248-58. PMID:22325774<ref>PMID:22325774</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22325774}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3leg" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 22325774 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_22325774}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[3leg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEG OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022325774</ref><references group="xtra"/>
+
[[Category: Streptococcus mitis]]
[[Category: Streptococcus mitis]]
-
[[Category: Feil, S C.]]
+
[[Category: Feil SC]]
-
[[Category: Blood clotting]]
+
-
[[Category: Lectin domain of lectinolysin]]
+
-
[[Category: Lewis y antigen]]
+
-
[[Category: Nickel]]
+

Current revision

Lectin Domain of Lectinolysin complexed with Lewis Y Antigen

PDB ID 3leg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3leg"
Personal tools