This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3qr8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:20, 8 June 2022) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3qr8.png|left|200px]]
 
-
<!--
+
==Crystal structure of the bacteriophage P2 membrane-piercing protein gpV==
-
The line below this paragraph, containing "STRUCTURE_3qr8", creates the "Structure Box" on the page.
+
<StructureSection load='3qr8' size='340' side='right'caption='[[3qr8]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3qr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpp2 Bpp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QR8 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
-->
+
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
{{STRUCTURE_3qr8| PDB=3qr8 | SCENE= }}
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qr7|3qr7]]</div></td></tr>
 +
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">V ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10679 BPP2])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr8 OCA], [https://pdbe.org/3qr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qr8 RCSB], [https://www.ebi.ac.uk/pdbsum/3qr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qr8 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[https://www.uniprot.org/uniprot/VPV_BPP2 VPV_BPP2]] Forms the small spike at the tip of the tail.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Bacteriophages with contractile tails and the bacterial type VI secretion system have been proposed to use a special protein to create an opening in the host cell membrane during infection. These proteins have a modular architecture but invariably contain an oligonucleotide/oligosaccharide-binding (OB-fold) domain and a long beta-helical C-terminal domain, which initiates the contact with the host cell membrane. Using X-ray crystallography and electron microscopy, we report the atomic structure of the membrane-piercing proteins from bacteriophages P2 and varphi92 and identify the residues that constitute the membrane-attacking apex. Both proteins form compact spikes with a approximately 10A diameter tip that is stabilized by a centrally positioned iron ion bound by six histidine residues. The accumulated data strongly suggest that, in the process of membrane penetration, the spikes are translocated through the lipid bilayer without undergoing major unfolding.
-
===Crystal structure of the bacteriophage P2 membrane-piercing protein gpV===
+
Phage pierces the host cell membrane with the iron-loaded spike.,Browning C, Shneider MM, Bowman VD, Schwarzer D, Leiman PG Structure. 2012 Feb 8;20(2):326-39. PMID:22325780<ref>PMID:22325780</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22325780}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3qr8" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 22325780 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_22325780}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Bpp2]]
-
[[3qr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p2 Enterobacteria phage p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR8 OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Browning, C]]
-
==Reference==
+
[[Category: Leiman, P G]]
-
<ref group="xtra">PMID:022325780</ref><references group="xtra"/>
+
[[Category: Shneider, M]]
-
[[Category: Enterobacteria phage p2]]
+
-
[[Category: Browning, C.]]
+
-
[[Category: Leiman, P G.]]
+
-
[[Category: Shneider, M.]]
+
[[Category: Beta-helix]]
[[Category: Beta-helix]]
[[Category: Cell membrane piercing]]
[[Category: Cell membrane piercing]]

Current revision

Crystal structure of the bacteriophage P2 membrane-piercing protein gpV

PDB ID 3qr8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3qr8"
Personal tools