2qxw

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[[Image:2qxw.png|left|200px]]
 
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==Perdeuterated alr2 in complex with idd594==
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The line below this paragraph, containing "STRUCTURE_2qxw", creates the "Structure Box" on the page.
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<StructureSection load='2qxw' size='340' side='right'caption='[[2qxw]], [[Resolution|resolution]] 0.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QXW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LDT:IDD594'>LDT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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{{STRUCTURE_2qxw| PDB=2qxw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxw OCA], [https://pdbe.org/2qxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qxw RCSB], [https://www.ebi.ac.uk/pdbsum/2qxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qxw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/2qxw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qxw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present results of combined studies of the enzyme human aldose reductase (h-AR, 36 kDa) using single-crystal x-ray data (0.66 A, 100K; 0.80 A, 15K; 1.75 A, 293K), neutron Laue data (2.2 A, 293K), and quantum mechanical modeling. These complementary techniques unveil the internal organization and mobility of the hydrogen bond network that defines the properties of the catalytic engine, explaining how this promiscuous enzyme overcomes the simultaneous requirements of efficiency and promiscuity offering a general mechanistic view for this class of enzymes.
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===Perdeuterated alr2 in complex with idd594===
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Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase.,Blakeley MP, Ruiz F, Cachau R, Hazemann I, Meilleur F, Mitschler A, Ginell S, Afonine P, Ventura ON, Cousido-Siah A, Haertlein M, Joachimiak A, Myles D, Podjarny A Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1844-8. Epub 2008 Feb 4. PMID:18250329<ref>PMID:18250329</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18250329}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2qxw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18250329 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18250329}}
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==About this Structure==
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[[2qxw]] is a 1 chain structure of [[Aldose Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXW OCA].
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==See Also==
==See Also==
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*[[Aldose Reductase]]
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018250329</ref><references group="xtra"/>
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__TOC__
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[[Category: Aldehyde reductase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Afonine, P.]]
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[[Category: Large Structures]]
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[[Category: Blakeley, M P.]]
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[[Category: Afonine P]]
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[[Category: Cachau, R.]]
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[[Category: Blakeley MP]]
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[[Category: Cousido-Siah, A.]]
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[[Category: Cachau R]]
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[[Category: Ginell, S.]]
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[[Category: Cousido-Siah A]]
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[[Category: Hazemann, I.]]
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[[Category: Ginell S]]
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[[Category: Joachimiak, A.]]
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[[Category: Hazemann I]]
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[[Category: Meilleur, F.]]
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[[Category: Joachimiak A]]
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[[Category: Mitschler, A.]]
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[[Category: Meilleur F]]
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[[Category: Myles, D.]]
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[[Category: Mitschler A]]
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[[Category: Podjarny, A.]]
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[[Category: Myles D]]
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[[Category: Ruiz, F.]]
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[[Category: Podjarny A]]
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[[Category: Ventura, O.]]
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[[Category: Ruiz F]]
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[[Category: Cataract]]
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[[Category: Ventura O]]
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[[Category: Idd594]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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Current revision

Perdeuterated alr2 in complex with idd594

PDB ID 2qxw

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