4dv8

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(New page: '''Unreleased structure''' The entry 4dv8 is ON HOLD Authors: Margosiak, S.A., Sankaran, B. Description: Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid bas...)
Current revision (11:00, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4dv8 is ON HOLD
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==Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421==
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<StructureSection load='4dv8' size='340' side='right'caption='[[4dv8]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4dv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DV8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.632&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LX:(2S)-6-[(4-FLUOROBENZYL)AMINO]-2-[(2R)-2-(4-FLUOROPHENYL)-2-METHOXYETHYL]-N-HYDROXYHEXANAMIDE'>0LX</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dv8 OCA], [https://pdbe.org/4dv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dv8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEF_BACAN LEF_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.<ref>PMID:9563949</ref> <ref>PMID:9703991</ref> <ref>PMID:10475971</ref> <ref>PMID:11104681</ref> <ref>PMID:10338520</ref>
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Authors: Margosiak, S.A., Sankaran, B.
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==See Also==
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*[[Anthrax lethal factor 3D structures|Anthrax lethal factor 3D structures]]
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Description: Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bacillus anthracis]]
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[[Category: Large Structures]]
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[[Category: Margosiak SA]]
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[[Category: Sankaran B]]

Current revision

Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421

PDB ID 4dv8

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