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4drz

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[[Image:4drz.jpg|left|200px]]
 
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==Crystal structure of human RAB14==
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The line below this paragraph, containing "STRUCTURE_4drz", creates the "Structure Box" on the page.
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<StructureSection load='4drz' size='340' side='right'caption='[[4drz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4drz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2aed 2aed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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{{STRUCTURE_4drz| PDB=4drz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drz OCA], [https://pdbe.org/4drz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drz RCSB], [https://www.ebi.ac.uk/pdbsum/4drz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB14_HUMAN RAB14_HUMAN] Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.<ref>PMID:22595670</ref>
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===Crystal structure of human RAB14===
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==See Also==
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4drz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2aed 2aed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRZ OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M.]]
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[[Category: Bochkarev A]]
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[[Category: Park, H.]]
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[[Category: Edwards AM]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Gtp]]
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[[Category: Gtpase]]
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[[Category: Oncogene]]
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[[Category: Protein transport]]
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[[Category: Rab14]]
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[[Category: Ra]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of human RAB14

PDB ID 4drz

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