3ug9

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[[Image:3ug9.png|left|200px]]
 
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==Crystal Structure of the Closed State of Channelrhodopsin==
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The line below this paragraph, containing "STRUCTURE_3ug9", creates the "Structure Box" on the page.
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<StructureSection load='3ug9' size='340' side='right'caption='[[3ug9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ug9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlre Chlre]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UG9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3uga|3uga]]</div></td></tr>
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{{STRUCTURE_3ug9| PDB=3ug9 | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">acop1, acop2, CHLREDRAFT_182032, cop4, CSOB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 CHLRE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ug9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ug9 OCA], [https://pdbe.org/3ug9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ug9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ug9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ug9 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Channelrhodopsins (ChRs) are light-gated cation channels derived from algae that have shown experimental utility in optogenetics; for example, neurons expressing ChRs can be optically controlled with high temporal precision within systems as complex as freely moving mammals. Although ChRs have been broadly applied to neuroscience research, little is known about the molecular mechanisms by which these unusual and powerful proteins operate. Here we present the crystal structure of a ChR (a C1C2 chimaera between ChR1 and ChR2 from Chlamydomonas reinhardtii) at 2.3 A resolution. The structure reveals the essential molecular architecture of ChRs, including the retinal-binding pocket and cation conduction pathway. This integration of structural and electrophysiological analyses provides insight into the molecular basis for the remarkable function of ChRs, and paves the way for the precise and principled design of ChR variants with novel properties.
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===Crystal structure of a protein===
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Crystal structure of the channelrhodopsin light-gated cation channel.,Kato HE, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S, Hegemann P, Maturana AD, Ishitani R, Deisseroth K, Nureki O Nature. 2012 Jan 22;482(7385):369-74. doi: 10.1038/nature10870. PMID:22266941<ref>PMID:22266941</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ug9" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22266941 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22266941}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Chlre]]
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[[3ug9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UG9 OCA].
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[[Category: Large Structures]]
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[[Category: Ishitani, R]]
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==Reference==
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[[Category: Kato, H E]]
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<ref group="xtra">PMID:022266941</ref><references group="xtra"/>
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[[Category: Nureki, O]]
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[[Category: Chlamydomonas reinhardtii]]
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[[Category: Ishitani, R.]]
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[[Category: Kato, H E.]]
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[[Category: Nureki, O.]]
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[[Category: Light-gated cation channel]]
[[Category: Light-gated cation channel]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Microbialrhodopsin]]
[[Category: Microbialrhodopsin]]
[[Category: Seven-transmembrane]]
[[Category: Seven-transmembrane]]

Current revision

Crystal Structure of the Closed State of Channelrhodopsin

PDB ID 3ug9

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