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4acu

From Proteopedia

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[[Image:4acu.jpg|left|200px]]
 
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==Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 14==
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The line below this paragraph, containing "STRUCTURE_4acu", creates the "Structure Box" on the page.
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<StructureSection load='4acu' size='340' side='right'caption='[[4acu]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4acu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=QN7:(8S)-3,3-DIFLUORO-8-(2-FLUORO-3-METHOXYBIPHENYL-3-YL)-8-PYRIDIN-4-YL-2,3,4,8-TETRAHYDROIMIDAZO[1,5-A]PYRIMIDIN-6-AMINE'>QN7</scene></td></tr>
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{{STRUCTURE_4acu| PDB=4acu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4acu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acu OCA], [https://pdbe.org/4acu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4acu RCSB], [https://www.ebi.ac.uk/pdbsum/4acu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4acu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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===Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 14===
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==See Also==
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22325942}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22325942 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22325942}}
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==About this Structure==
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[[4acu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACU OCA].
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==Reference==
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<ref group="xtra">PMID:022325942</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Large Structures]]
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[[Category: Berg, S.]]
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[[Category: Berg S]]
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[[Category: Ek, M.]]
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[[Category: Ek M]]
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[[Category: Falting, J.]]
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[[Category: Falting J]]
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[[Category: Georgievska, B.]]
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[[Category: Georgievska B]]
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[[Category: Gustavsson, S.]]
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[[Category: Gustavsson S]]
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[[Category: Holenz, J.]]
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[[Category: Holenz J]]
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[[Category: Kihlstrom, J.]]
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[[Category: Kihlstrom J]]
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[[Category: Kolmodin, K.]]
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[[Category: Kolmodin K]]
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[[Category: Lindstrom, J.]]
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[[Category: Lindstrom J]]
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[[Category: Neelissen, J.]]
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[[Category: Neelissen J]]
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[[Category: Olsson, L L.]]
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[[Category: Olsson LL]]
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[[Category: Plobeck, N.]]
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[[Category: Plobeck N]]
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[[Category: Rotticci, D.]]
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[[Category: Rotticci D]]
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[[Category: Sehgelmeble, F.]]
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[[Category: Sehgelmeble F]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Swahn, B.]]
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[[Category: Swahn B]]
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[[Category: Vonberg, S.]]
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[[Category: Von Berg S]]
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[[Category: Alzheimer's disease]]
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[[Category: Hydrolase]]
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Current revision

Aminoimidazoles as BACE-1 Inhibitors. X-RAY CRYSTAL STRUCTURE OF BETA SECRETASE COMPLEXED WITH COMPOUND 14

PDB ID 4acu

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