3v47

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:33, 6 November 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3v47.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the N-terminal fragment of zebrafish TLR5 in complex with Salmonella flagellin==
-
The line below this paragraph, containing "STRUCTURE_3v47", creates the "Structure Box" on the page.
+
<StructureSection load='3v47' size='340' side='right'caption='[[3v47]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3v47]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio], [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Dublin Salmonella enterica subsp. enterica serovar Dublin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V47 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
{{STRUCTURE_3v47| PDB=3v47 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v47 OCA], [https://pdbe.org/3v47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v47 RCSB], [https://www.ebi.ac.uk/pdbsum/3v47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v47 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/B3DIN1_DANRE B3DIN1_DANRE] [https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Toll-like receptor 5 (TLR5) binding to bacterial flagellin activates signaling through the transcription factor NF-kappaB and triggers an innate immune response to the invading pathogen. To elucidate the structural basis and mechanistic implications of TLR5-flagellin recognition, we determined the crystal structure of zebrafish TLR5 (as a variable lymphocyte receptor hybrid protein) in complex with the D1/D2/D3 fragment of Salmonella flagellin, FliC, at 2.47 angstrom resolution. TLR5 interacts primarily with the three helices of the FliC D1 domain using its lateral side. Two TLR5-FliC 1:1 heterodimers assemble into a 2:2 tail-to-tail signaling complex that is stabilized by quaternary contacts of the FliC D1 domain with the convex surface of the opposing TLR5. The proposed signaling mechanism is supported by structure-guided mutagenesis and deletion analyses on CBLB502, a therapeutic protein derived from FliC.
-
===The Crystal structure of an innate immune receptor in complex with its ligand===
+
Structural basis of TLR5-flagellin recognition and signaling.,Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA Science. 2012 Feb 17;335(6070):859-64. PMID:22344444<ref>PMID:22344444</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3v47" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_22344444}}, adds the Publication Abstract to the page
+
*[[Flagellin|Flagellin]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 22344444 is the PubMed ID number.
+
*[[Flagellin 3D structures|Flagellin 3D structures]]
-
-->
+
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
-
{{ABSTRACT_PUBMED_22344444}}
+
*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[3v47]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio,_eptatretus_burgeri Danio rerio, eptatretus burgeri] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_dublin Salmonella enterica subsp. enterica serovar dublin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V47 OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
[[Category: Danio rerio]]
-
<ref group="xtra">PMID:022344444</ref><references group="xtra"/>
+
[[Category: Eptatretus burgeri]]
-
[[Category: Danio rerio, eptatretus burgeri]]
+
[[Category: Large Structures]]
-
[[Category: Salmonella enterica subsp. enterica serovar dublin]]
+
[[Category: Salmonella enterica subsp. enterica serovar Dublin]]
-
[[Category: Hong, H.]]
+
[[Category: Hong H]]
-
[[Category: Wilson, I A.]]
+
[[Category: Wilson IA]]
-
[[Category: Yoon, S I.]]
+
[[Category: Yoon SI]]
-
[[Category: Immune system]]
+
-
[[Category: Innate immune receptor]]
+
-
[[Category: Innate immunity]]
+
-
[[Category: Leucine-rich repeat]]
+

Current revision

Crystal structure of the N-terminal fragment of zebrafish TLR5 in complex with Salmonella flagellin

PDB ID 3v47

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3v47"
Personal tools