3zta

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:37, 6 November 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3zta.png|left|200px]]
 
-
<!--
+
==The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling==
-
The line below this paragraph, containing "STRUCTURE_3zta", creates the "Structure Box" on the page.
+
<StructureSection load='3zta' size='340' side='right'caption='[[3zta]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3zta]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZTA FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
{{STRUCTURE_3zta| PDB=3zta | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zta OCA], [https://pdbe.org/3zta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zta RCSB], [https://www.ebi.ac.uk/pdbsum/3zta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zta ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q2RIF4_MOOTA Q2RIF4_MOOTA]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The stressosome complex regulates downstream effectors in response to environmental signals. In Bacillus subtilis, it activates the alternative sigma factor sigma(B), leading to the upregulation of the general stress regulon. Herein, we characterize a stressosome-regulated biochemical pathway in Moorella thermoacetica. We show that the presumed sensor, MtR, and the scaffold, MtS, form a pseudo-icosahedral structure like that observed in B. subtilis. The N-terminal domain of MtR is structurally homologous to B. subtilis RsbR, despite low sequence identity. The affinity of the switch kinase, MtT, for MtS decreases following MtS phosphorylation and not because of structural reorganization. Dephosphorylation of MtS by the PP2C type phosphatase MtX permits the switch kinase to rebind the stressosome to reset the response. We also show that MtT regulates cyclic di-GMP biosynthesis through inhibition of a GG(D/E)EF-type diguanylate cyclase, demonstrating that secondary messenger levels are regulated by the stressosome.
-
===The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling===
+
The Bacterial Stressosome: A Modular System that Has Been Adapted to Control Secondary Messenger Signaling.,Quin MB, Berrisford JM, Newman JA, Basle A, Lewis RJ, Marles-Wright J Structure. 2012 Feb 8;20(2):350-63. PMID:22325782<ref>PMID:22325782</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3zta" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_22325782}}, adds the Publication Abstract to the page
+
*[[Anti-sigma factor antagonist 3D structures|Anti-sigma factor antagonist 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 22325782 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_22325782}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[3zta]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTA OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022325782</ref><references group="xtra"/>
+
[[Category: Moorella thermoacetica]]
[[Category: Moorella thermoacetica]]
-
[[Category: Basle, A.]]
+
[[Category: Basle A]]
-
[[Category: Berrisford, J M.]]
+
[[Category: Berrisford JM]]
-
[[Category: Lewis, R J.]]
+
[[Category: Lewis RJ]]
-
[[Category: Marles-Wright, J.]]
+
[[Category: Marles-Wright J]]
-
[[Category: Newman, J A.]]
+
[[Category: Newman JA]]
-
[[Category: Quin, M B.]]
+
[[Category: Quin MB]]
-
[[Category: Phosphorylation]]
+
-
[[Category: Protein-protein interaction]]
+
-
[[Category: Rsb]]
+
-
[[Category: Signal transduction]]
+
-
[[Category: Signaling]]
+
-
[[Category: Type 2c phosphatase]]
+

Current revision

The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling

PDB ID 3zta

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3zta"
Personal tools