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3rtq

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[[Image:3rtq.png|left|200px]]
 
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==Structure of the mouse CD1d-HS44-iNKT TCR complex==
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The line below this paragraph, containing "STRUCTURE_3rtq", creates the "Structure Box" on the page.
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<StructureSection load='3rtq' size='340' side='right'caption='[[3rtq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rtq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RTQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=H4S:N-[(2S,3S,4R)-3,4-DIHYDROXY-1-{[(1S,2S,3R,4R,5S)-2,3,4,5-TETRAHYDROXYCYCLOHEXYL]AMINO}OCTADECAN-2-YL]HEXACOSANAMIDE'>H4S</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd1.1, CD1d, Cd1d1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Valpha14 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Vbeta8.2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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{{STRUCTURE_3rtq| PDB=3rtq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtq OCA], [https://pdbe.org/3rtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rtq RCSB], [https://www.ebi.ac.uk/pdbsum/3rtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rtq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Activation of type I NKT (iNKT) cells by CD1d-presented agonists is a potent immunotherapeutic tool. alpha-Galactosylceramide (alpha-GalCer) is the prototypic agonist, but its excessive potency with simultaneous production of both pro- and anti-inflammatory cytokines hampers its potential therapeutic use. In search for novel agonists, we have analyzed the structure and function of HS44, a synthetic aminocyclitolic ceramide analog designed to avoid unrestrained iNKT cell activation. HS44 is a weaker agonist compared with alpha-GalCer in vitro, although in vivo it induces robust IFN-gamma production, and highly reduced but still functional Th2 response. The characteristic cytokine storm produced upon alpha-GalCer activation was not induced. Consequently, HS44 induced a very efficient iNKT cell-dependent antitumoral response in B16 animal model. In addition, intranasal administration showed the capacity to induce lung inflammation and airway hyperreactivity, a cardinal asthma feature. Thus, HS44 is able to elicit functional Th1 or Th2 responses. Structural studies show that HS44 binds to CD1d with the same conformation as alpha-GalCer. The TCR binds to HS44 similarly as alpha-GalCer, but forms less contacts, thus explaining its weaker TCR affinity and, consequently, its weaker recognition by iNKT cells. The ability of this compound to activate an efficient, but not massive, tailored functional immune response makes it an attractive reagent for immune manipulation.
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===Structure of the mouse CD1d-HS44-iNKT TCR complex===
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Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties.,Kerzerho J, Yu ED, Barra CM, Alari-Pahisa E, Girardi E, Harrak Y, Lauzurica P, Llebaria A, Zajonc DM, Akbari O, Castano AR J Immunol. 2012 Mar 1;188(5):2254-65. Epub 2012 Feb 1. PMID:22301545<ref>PMID:22301545</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rtq" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22301545}}, adds the Publication Abstract to the page
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22301545 is the PubMed ID number.
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*[[CD1|CD1]]
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== References ==
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{{ABSTRACT_PUBMED_22301545}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3rtq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTQ OCA].
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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==Reference==
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[[Category: Yu, E D]]
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<ref group="xtra">PMID:022301545</ref><references group="xtra"/>
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[[Category: Zajonc, D M]]
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[[Category: Mus musculus]]
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[[Category: Yu, E D.]]
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[[Category: Zajonc, D M.]]
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[[Category: Antigen presentation]]
[[Category: Antigen presentation]]
[[Category: Glycolipid]]
[[Category: Glycolipid]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Nkt cell]]
[[Category: Nkt cell]]

Current revision

Structure of the mouse CD1d-HS44-iNKT TCR complex

PDB ID 3rtq

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