2lpb

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[[Image:2lpb.png|left|200px]]
 
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==Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15==
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The line below this paragraph, containing "STRUCTURE_2lpb", creates the "Structure Box" on the page.
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<StructureSection load='2lpb' size='340' side='right'caption='[[2lpb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lpb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ko4 2ko4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LPB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpb OCA], [https://pdbe.org/2lpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lpb RCSB], [https://www.ebi.ac.uk/pdbsum/2lpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpb ProSAT]</span></td></tr>
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{{STRUCTURE_2lpb| PDB=2lpb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MED15_YEAST MED15_YEAST] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. It has an important role in the negative regulation of Ty transcription.<ref>PMID:16076843</ref> <ref>PMID:16109375</ref> <ref>PMID:16263706</ref>
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===Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15===
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==See Also==
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*[[Gcn4 3D Structures|Gcn4 3D Structures]]
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*[[Gnc4 3D Structures|Gnc4 3D Structures]]
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*[[Mediator|Mediator]]
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22195967 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22195967}}
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Saccharomyces cerevisiae S288C]]
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[[2lpb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ko4 2ko4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPB OCA].
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[[Category: Baker D]]
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[[Category: Brzovic PS]]
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==Reference==
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[[Category: Hahn S]]
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<ref group="xtra">PMID:022195967</ref><references group="xtra"/>
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[[Category: Heikaus CC]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Herbig E]]
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[[Category: Baker, D.]]
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[[Category: Kisselev L]]
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[[Category: Brzovic, P S.]]
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[[Category: Klevit RE]]
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[[Category: Hahn, S.]]
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[[Category: Littlefield P]]
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[[Category: Heikaus, C C.]]
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[[Category: Pacheco D]]
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[[Category: Herbig, E.]]
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[[Category: Vernon R]]
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[[Category: Kisselev, L.]]
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[[Category: Warfield L]]
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[[Category: Klevit, R E.]]
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[[Category: Littlefield, P.]]
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[[Category: Pacheco, D.]]
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[[Category: Vernon, R.]]
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[[Category: Warfield, L.]]
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[[Category: Activator]]
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[[Category: Amino acid biosynthesis]]
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[[Category: Co-activator]]
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[[Category: Dna-binding]]
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[[Category: Mediator]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15

PDB ID 2lpb

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