3sav

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[[Image:3sav.png|left|200px]]
 
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==MUTM Slanted complex 8==
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The line below this paragraph, containing "STRUCTURE_3sav", creates the "Structure Box" on the page.
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<StructureSection load='3sav' size='340' side='right'caption='[[3sav]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sav]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SAV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.125&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CX2:2-DEOXY-5-O-{(R)-HYDROXY[(2-SULFANYLETHYL)AMINO]PHOSPHORYL}CYTIDINE'>CX2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3sav| PDB=3sav | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sav OCA], [https://pdbe.org/3sav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sav RCSB], [https://www.ebi.ac.uk/pdbsum/3sav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sav ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]
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===MUTM Slanted complex 8===
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==See Also==
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 22219368 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22219368}}
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==About this Structure==
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[[3sav]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAV OCA].
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==Reference==
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<ref group="xtra">PMID:022219368</ref><references group="xtra"/>
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[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Qi, Y.]]
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[[Category: Large Structures]]
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[[Category: Spong, M C.]]
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[[Category: Qi Y]]
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[[Category: Verdine, G L.]]
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[[Category: Spong MC]]
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[[Category: Damage search]]
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[[Category: Verdine GL]]
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[[Category: Disulfide crosslinking]]
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[[Category: Dna damage]]
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[[Category: Dna glycosylase]]
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[[Category: Dna repair]]
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[[Category: Dna-binding]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Lyase]]
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[[Category: Metal-binding]]
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[[Category: Multifunctional enzyme]]
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[[Category: Translocation]]
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[[Category: Zinc-finger]]
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Current revision

MUTM Slanted complex 8

PDB ID 3sav

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