3sy2

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[[Image:3sy2.png|left|200px]]
 
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==Crystal structure of the Salmonella E3 ubiquitin ligase SopA in complex with the human E2 UbcH7==
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The line below this paragraph, containing "STRUCTURE_3sy2", creates the "Structure Box" on the page.
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<StructureSection load='3sy2' size='340' side='right'caption='[[3sy2]], [[Resolution|resolution]] 3.27&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sy2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SY2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.27&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3sy2| PDB=3sy2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sy2 OCA], [https://pdbe.org/3sy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sy2 RCSB], [https://www.ebi.ac.uk/pdbsum/3sy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sy2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SOPA_SALTY SOPA_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Required for inducing polymorphonuclear leukocytes migration across the intestinal epithelium. Preferentially uses host UBE2D1 (UBCH5A), UBE2D2 (UBCH5B) and UBE2L3 (UBCH7) as E2 ubiquitin-conjugating enzymes.<ref>PMID:17076670</ref> <ref>PMID:18066077</ref>
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===Crystal structure of the Salmonella E3 ubiquitin ligase SopA in complex with the human E2 UbcH7===
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
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== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 22308380 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_22308380}}
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==About this Structure==
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[[3sy2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SY2 OCA].
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==Reference==
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<ref group="xtra">PMID:022308380</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Large Structures]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Chen, J.]]
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[[Category: Chen J]]
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[[Category: Diao, J.]]
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[[Category: Diao J]]
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[[Category: Lin, D Y.]]
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[[Category: Lin DY]]
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[[Category: E2 ubiquitin conjugating enzyme]]
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[[Category: Effector protein]]
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[[Category: Hect domain]]
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[[Category: Hect e3]]
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[[Category: Hect e3 ubiquitin ligase]]
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[[Category: Ligase-signaling protein complex]]
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[[Category: Pentapeptide]]
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[[Category: Protein-protein complex]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin transfer]]
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[[Category: Ubiquitination]]
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Current revision

Crystal structure of the Salmonella E3 ubiquitin ligase SopA in complex with the human E2 UbcH7

PDB ID 3sy2

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OCA

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