2lfg

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[[Image:2lfg.png|left|200px]]
 
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==Solution structure of the human prolactin receptor ecd domain d2==
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The line below this paragraph, containing "STRUCTURE_2lfg", creates the "Structure Box" on the page.
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<StructureSection load='2lfg' size='340' side='right'caption='[[2lfg]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lfg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LFG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lfg OCA], [https://pdbe.org/2lfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lfg RCSB], [https://www.ebi.ac.uk/pdbsum/2lfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lfg ProSAT]</span></td></tr>
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{{STRUCTURE_2lfg| PDB=2lfg | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The prolactin receptor (PRLR) is activated by binding of prolactin in a 2:1 complex, but the activation mechanism is poorly understood. PRLR has a conserved WSXWS motif generic to cytokine class I receptors. We have determined the nuclear magnetic resonance solution structure of the membrane proximal domain of the human PRLR and find that the tryptophans of the motif adopt a T-stack conformation in the unbound state. By contrast, in the hormone bound state, a Trp/Arg-ladder is formed. The conformational change is hormone-dependent and influences the receptor-receptor dimerization site 3. In the constitutively active, breast cancer-related receptor mutant PRLR(I146L), we observed a stabilization of the dimeric state and a change in the dynamics of the motif. Here we demonstrate a structural link between the WSXWS motif, hormone binding, and receptor dimerization and propose it as a general mechanism for class 1 receptor activation.
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===Solution structure of the human prolactin receptor ecd domain d2===
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The WSXWS Motif in Cytokine Receptors Is a Molecular Switch Involved in Receptor Activation: Insight from Structures of the Prolactin Receptor.,Dagil R, Knudsen MJ, Olsen JG, O'Shea C, Franzmann M, Goffin V, Teilum K, Breinholt J, Kragelund BB Structure. 2012 Feb 8;20(2):270-82. PMID:22325776<ref>PMID:22325776</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2lfg" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22325776}}, adds the Publication Abstract to the page
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*[[Prolactin receptor|Prolactin receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22325776 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22325776}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lfg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFG OCA].
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==Reference==
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<ref group="xtra">PMID:022325776</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dagil, R.]]
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[[Category: Large Structures]]
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[[Category: Knudsen, M J.]]
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[[Category: Dagil R]]
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[[Category: Kragelund, B B.]]
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[[Category: Knudsen MJ]]
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[[Category: Shea, C O.]]
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[[Category: Kragelund BB]]
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[[Category: Teilum, K.]]
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[[Category: O'Shea C]]
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[[Category: Cytokine receptor]]
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[[Category: Teilum K]]
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[[Category: Extracellular domain]]
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[[Category: Hormone receptor]]
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Current revision

Solution structure of the human prolactin receptor ecd domain d2

PDB ID 2lfg

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