2yik

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[[Image:2yik.jpg|left|200px]]
 
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==Catalytic domain of Clostridium thermocellum CelT==
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The line below this paragraph, containing "STRUCTURE_2yik", creates the "Structure Box" on the page.
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<StructureSection load='2yik' size='340' side='right'caption='[[2yik]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_thermocellus Acetivibrio thermocellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YIK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2yik| PDB=2yik | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yik OCA], [https://pdbe.org/2yik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yik RCSB], [https://www.ebi.ac.uk/pdbsum/2yik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yik ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A3DJ82_ACET2 A3DJ82_ACET2]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cellulases hydrolyze cellulose, a major component of plant cell walls, to oligosaccharides and monosaccharides. Several Clostridium species secrete multi-enzyme complexes (cellulosomes) containing cellulases. C. thermocellum CelT, a family 9 cellulase, lacks the accessory module(s) necessary for activity, unlike most other family 9 cellulases. Therefore, characterization of the CelT structure is essential in order to understand its catalytic mechanism. Here, the crystal structure of free CelTDeltadoc, the catalytic domain of CelT, is reported at 2.1 A resolution. Its structure differs in several aspects from those of other family 9 cellulases. CelTDeltadoc contains an additional alpha-helix, alpha-helices of increased length and two additional surface-exposed beta-strands. It also contains three calcium ions instead of one as found in C. cellulolyticum Cel9M. CelTDeltadoc also has two flexible loops at the open end of its active-site cleft. Movement of these loops probably allows the substrate to access the active site. CelT is stable over a wide range of pH and temperature conditions, suggesting that CelT could be used to convert cellulose biomass into biofuel.
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===Catalytic domain of Clostridium thermocellum CelT===
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Structure of the catalytic domain of the Clostridium thermocellum cellulase CelT.,Kesavulu MM, Tsai JY, Lee HL, Liang PH, Hsiao CD Acta Crystallogr D Biol Crystallogr. 2012 Mar;68(Pt 3):310-20. Epub 2012 Feb 14. PMID:22349233<ref>PMID:22349233</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[2yik]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIK OCA].
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<div class="pdbe-citations 2yik" style="background-color:#fffaf0;"></div>
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[[Category: Cellulase]]
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== References ==
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[[Category: Clostridium thermocellum]]
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<references/>
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[[Category: Hsiao, C D.]]
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__TOC__
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[[Category: Kesavulu, M M.]]
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</StructureSection>
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[[Category: Tsai, J Y.]]
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[[Category: Acetivibrio thermocellus]]
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[[Category: Hydrolase]]
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[[Category: Large Structures]]
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[[Category: Hsiao C-D]]
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[[Category: Kesavulu MM]]
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[[Category: Tsai J-Y]]

Current revision

Catalytic domain of Clostridium thermocellum CelT

PDB ID 2yik

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