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Methylcitrate synthase
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| - | + | <StructureSection load='3o8j' size='350' side='right' caption='Methylcitrate synthase dimer complex with glycerol (PDB entry [[3o8j]])' scene=''> | |
| + | == Function == | ||
| + | '''Methylcitrate synthase''' (MCS) participates in propanoate metabolism. It catalyzes the conversion of acyl to alkyl group in the reaction which converts propanoyl-CoA and oxaloacetate to 2-hydroxybutane-1,2,3-tricarboxylate and CoA<ref>PMID:10482501</ref>. The metabolism of propionyl-CoA in microorganism is performed by the methylcitrate cycle. The methylcitrate cycle contains MCS, methylcitrate dehydrogenase and methylisocitrate lyase<ref>PMID:18048912</ref>. The methylcitrate cycle can serve as a carbon and energy source of growth. In the presence of glucose, the cycle serves to remove the toxic propionate. | ||
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| + | == Relevance == | ||
| + | The high levels of propionate used to preserve foodstuffs lead to fungal growth inhibition via the accumulation of intermediates of the methylcitrate cycle<ref>PMID:10712680</ref>. | ||
| - | + | See also [[Citrate Synthase]]. | |
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| + | </StructureSection> | ||
==3D structures of methylcitrate synthase== | ==3D structures of methylcitrate synthase== | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[3hwk]] – MCS – ''Mycobacterium tuberculosis''<br /> | [[3hwk]] – MCS – ''Mycobacterium tuberculosis''<br /> | ||
[[3o8j]] – MCS – ''Salmonella enterica''<br /> | [[3o8j]] – MCS – ''Salmonella enterica''<br /> | ||
| - | [[3tqg]] – MCS – ''Coxiella burnetii'' | + | [[3tqg]] – MCS – ''Coxiella burnetii''<br /> |
| + | [[5uqo]], [[5uqq]], [[5uqr]] – Af2-MCS – ''Aspergillus fumigata''<br /> | ||
| + | [[5uqu]], [[6bom]], [[6bop]] – Af2-MCS (mutant)<br /> | ||
| + | [[6bol]] – Af2-MCS (mutant) + oxaloacetate<br /> | ||
| + | [[6bon]], [[6boo]] – Af2-MCS + oxaloacetate + CoA<br /> | ||
| + | [[6s6f]] – Pa2-MCS – ''Pseudomonas aeruginosa''<br /> | ||
| + | [[6s87]] – Pa2-MCS + oxaloacetate <br /> | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of methylcitrate synthase
Updated on 02-November-2021
3hwk – MCS – Mycobacterium tuberculosis
3o8j – MCS – Salmonella enterica
3tqg – MCS – Coxiella burnetii
5uqo, 5uqq, 5uqr – Af2-MCS – Aspergillus fumigata
5uqu, 6bom, 6bop – Af2-MCS (mutant)
6bol – Af2-MCS (mutant) + oxaloacetate
6bon, 6boo – Af2-MCS + oxaloacetate + CoA
6s6f – Pa2-MCS – Pseudomonas aeruginosa
6s87 – Pa2-MCS + oxaloacetate
References
- ↑ Horswill AR, Escalante-Semerena JC. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. J Bacteriol. 1999 Sep;181(18):5615-23. PMID:10482501
- ↑ Upton AM, McKinney JD. Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis. Microbiology. 2007 Dec;153(Pt 12):3973-82. PMID:18048912 doi:http://dx.doi.org/10.1099/mic.0.2007/011726-0
- ↑ Brock M, Fischer R, Linder D, Buckel W. Methylcitrate synthase from Aspergillus nidulans: implications for propionate as an antifungal agent. Mol Microbiol. 2000 Mar;35(5):961-73. PMID:10712680
