3qii

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[[Image:3qii.png|left|200px]]
 
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==Crystal structure of tudor domain 2 of human PHD finger protein 20==
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The line below this paragraph, containing "STRUCTURE_3qii", creates the "Structure Box" on the page.
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<StructureSection load='3qii' size='340' side='right'caption='[[3qii]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qii]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QII FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qii OCA], [https://pdbe.org/3qii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qii RCSB], [https://www.ebi.ac.uk/pdbsum/3qii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qii ProSAT]</span></td></tr>
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{{STRUCTURE_3qii| PDB=3qii | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHF20_HUMAN PHF20_HUMAN] Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.<ref>PMID:20018852</ref> <ref>PMID:22864287</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The human PHD finger protein 20 (PHF20) is a putative transcription factor. While little is known about its cognate cellular role, antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma, glioblastoma and childhood medulloblastula. PHF20 comprises two N-terminal Tudor domains, a central C2H2-link zinc finger domain and a C-terminal zinc-binding PHD domain, and is a component of some MLL methyltransferase complexes. Here, we report the crystal structures of the N-terminal Tudor domains of PHF20 and highlight the novel structural features of each domain. We also confirm previous studies suggesting that the second Tudor domain of PHF20 exhibits preference for dimethylated histone substrates.
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===Crystal structure of tudor domain 2 of human PHD finger protein 20===
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Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins.,Adams-Cioaba MA, Li Z, Tempel W, Guo Y, Bian C, Li Y, Lam R, Min J FEBS Lett. 2012 Mar 23;586(6):859-65. Epub 2012 Feb 24. PMID:22449972<ref>PMID:22449972</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3qii]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QII OCA].
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<div class="pdbe-citations 3qii" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bian, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bian C]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Chao, X.]]
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[[Category: Bountra C]]
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[[Category: Crombet, L.]]
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[[Category: Chao X]]
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[[Category: Edwards, A M.]]
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[[Category: Crombet L]]
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[[Category: Lam, R.]]
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[[Category: Edwards AM]]
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[[Category: Li, Z.]]
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[[Category: Lam R]]
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[[Category: Min, J.]]
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[[Category: Li Z]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Min J]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Wernimont, A K.]]
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[[Category: Wernimont AK]]
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[[Category: Phd finger]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transcription regulator]]
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[[Category: Tudor domain]]
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Current revision

Crystal structure of tudor domain 2 of human PHD finger protein 20

PDB ID 3qii

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