4di5

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[[Image:4di5.png|left|200px]]
 
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==Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline==
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The line below this paragraph, containing "STRUCTURE_4di5", creates the "Structure Box" on the page.
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<StructureSection load='4di5' size='340' side='right'caption='[[4di5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4di5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DI5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_4di5| PDB=4di5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4di5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4di5 OCA], [https://pdbe.org/4di5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4di5 RCSB], [https://www.ebi.ac.uk/pdbsum/4di5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4di5 ProSAT]</span></td></tr>
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</table>
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===Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline===
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== Function ==
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[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4di5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DI5 OCA].
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[[Category: Large Structures]]
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[[Category: 5-epiaristolochene synthase]]
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[[Category: Nicotiana tabacum]]
[[Category: Nicotiana tabacum]]
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[[Category: Crenshaw, C M.]]
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[[Category: Crenshaw CM]]
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[[Category: Noel, J P.]]
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[[Category: Noel JP]]
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[[Category: Starks, C.]]
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[[Category: Starks C]]
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[[Category: All helical]]
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[[Category: Inhibitor]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Pyrophosphate]]
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[[Category: Tea]]
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Current revision

Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline

PDB ID 4di5

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