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3v44

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[[Image:3v44.png|left|200px]]
 
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==Crystal structure of the N-terminal fragment of zebrafish TLR5==
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The line below this paragraph, containing "STRUCTURE_3v44", creates the "Structure Box" on the page.
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<StructureSection load='3v44' size='340' side='right'caption='[[3v44]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3v44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V44 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v47|3v47]]</div></td></tr>
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{{STRUCTURE_3v44| PDB=3v44 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v44 OCA], [https://pdbe.org/3v44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v44 RCSB], [https://www.ebi.ac.uk/pdbsum/3v44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v44 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Toll-like receptor 5 (TLR5) binding to bacterial flagellin activates signaling through the transcription factor NF-kappaB and triggers an innate immune response to the invading pathogen. To elucidate the structural basis and mechanistic implications of TLR5-flagellin recognition, we determined the crystal structure of zebrafish TLR5 (as a variable lymphocyte receptor hybrid protein) in complex with the D1/D2/D3 fragment of Salmonella flagellin, FliC, at 2.47 angstrom resolution. TLR5 interacts primarily with the three helices of the FliC D1 domain using its lateral side. Two TLR5-FliC 1:1 heterodimers assemble into a 2:2 tail-to-tail signaling complex that is stabilized by quaternary contacts of the FliC D1 domain with the convex surface of the opposing TLR5. The proposed signaling mechanism is supported by structure-guided mutagenesis and deletion analyses on CBLB502, a therapeutic protein derived from FliC.
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===Crystal structure of the N-terminal fragment of zebrafish TLR5===
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Structural basis of TLR5-flagellin recognition and signaling.,Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA Science. 2012 Feb 17;335(6070):859-64. PMID:22344444<ref>PMID:22344444</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3v44" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22344444}}, adds the Publication Abstract to the page
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22344444 is the PubMed ID number.
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_22344444}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3v44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio,_eptatretus_burgeri Danio rerio, eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V44 OCA].
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[[Category: Bdellostoma burgeri]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Hong, H]]
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<ref group="xtra">PMID:022344444</ref><references group="xtra"/>
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[[Category: Wilson, I A]]
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[[Category: Danio rerio, eptatretus burgeri]]
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[[Category: Yoon, S I]]
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[[Category: Hong, H.]]
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[[Category: Wilson, I A.]]
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[[Category: Yoon, S I.]]
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[[Category: Flagellin]]
[[Category: Flagellin]]
[[Category: Immune system]]
[[Category: Immune system]]

Current revision

Crystal structure of the N-terminal fragment of zebrafish TLR5

PDB ID 3v44

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