4drr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:43, 14 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4drr is ON HOLD until Paper Publication
+
==Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen==
 +
<StructureSection load='4drr' size='340' side='right'caption='[[4drr]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4drr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRR FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drr OCA], [https://pdbe.org/4drr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drr RCSB], [https://www.ebi.ac.uk/pdbsum/4drr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drr ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q86169_9REOV Q86169_9REOV] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880]
-
Authors: Hu, L., Crawford, S.E., Czako, R., Cortes-Penfield, N.W., Smith, D.F., Le Pendu, J., Estes, M.K., Prasad, B.V.V.
+
==See Also==
-
 
+
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-
Description: Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Rotavirus sp]]
 +
[[Category: Cortes-Penfield NW]]
 +
[[Category: Crawford SE]]
 +
[[Category: Czako R]]
 +
[[Category: Estes MK]]
 +
[[Category: Hu L]]
 +
[[Category: Le Pendu J]]
 +
[[Category: Prasad BVV]]
 +
[[Category: Smith DF]]

Current revision

Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen

PDB ID 4drr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4drr"
Personal tools