4dw6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4dw6 is ON HOLD Authors: Flipo, M., Willand, N., Lecat-Guillet, N., Hounsou, C., Desroses, M., Leroux, F., Lens, Z., Villeret, V., Wohlkonig, A., Wi...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.== | |
| + | <StructureSection load='4dw6' size='340' side='right'caption='[[4dw6]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4dw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DW6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0MN:N-[4-(1,3-BENZOTHIAZOL-2-YL)PHENYL]-2-(3-METHOXYPHENOXY)ACETAMIDE'>0MN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dw6 OCA], [https://pdbe.org/4dw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dw6 RCSB], [https://www.ebi.ac.uk/pdbsum/4dw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dw6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Baulard AR]] | ||
| + | [[Category: Brodin P]] | ||
| + | [[Category: Christophe T]] | ||
| + | [[Category: Deprez B]] | ||
| + | [[Category: Desroses M]] | ||
| + | [[Category: Flipo M]] | ||
| + | [[Category: Hounsou C]] | ||
| + | [[Category: Jeon HK]] | ||
| + | [[Category: Lecat-Guillet N]] | ||
| + | [[Category: Lens Z]] | ||
| + | [[Category: Leroux F]] | ||
| + | [[Category: Locht C]] | ||
| + | [[Category: Villeret V]] | ||
| + | [[Category: Willand N]] | ||
| + | [[Category: Wintjens R]] | ||
| + | [[Category: Wohlkonig A]] | ||
Current revision
Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.
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Categories: Large Structures | Mycobacterium tuberculosis | Baulard AR | Brodin P | Christophe T | Deprez B | Desroses M | Flipo M | Hounsou C | Jeon HK | Lecat-Guillet N | Lens Z | Leroux F | Locht C | Villeret V | Willand N | Wintjens R | Wohlkonig A
