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1cd8

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[[Image:1cd8.jpg|left|200px]]<br /><applet load="1cd8" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1cd8, resolution 2.6&Aring;" />
 
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'''CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION==
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A secreted fragment of the extracellular portion of human CD8 alpha has, been expressed in CHO cells, and a deglycosylated and proteolyzed form of, this fragment has been crystallized. We report here the crystal structure, of this fragment as refined at 2.6 A resolution. The structure was solved, by molecular replacement using a superposition of ten variable domains, from immunoglobulin light chains as the search model. Only the N-terminal, 114 amino acids of CD8 alpha are visible in the electron density maps. The, domain formed by these residues possesses a fold typical of immunoglobulin, variable domains and associates to form Fv-like homodimers.
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<StructureSection load='1cd8' size='340' side='right'caption='[[1cd8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cd8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CD8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cd8 OCA], [https://pdbe.org/1cd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cd8 RCSB], [https://www.ebi.ac.uk/pdbsum/1cd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cd8 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN] Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:[https://omim.org/entry/608957 608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
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== Function ==
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[https://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/1cd8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cd8 ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known diseases associated with this structure: CD8 deficiency, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186910 186910]], Megakaryoblastic leukemia, acute OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606078 606078]]
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*[[CD8 3D structures|CD8 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1CD8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CD8 OCA].
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Axel R]]
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Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution., Leahy DJ, Axel R, Hendrickson WA, Cell. 1992 Mar 20;68(6):1145-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1547508 1547508]
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[[Category: Hendrickson WA]]
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[[Category: Single protein]]
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[[Category: Leahy DJ]]
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[[Category: Axel, R.]]
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[[Category: Hendrickson, W.A.]]
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[[Category: Leahy, D.J.]]
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[[Category: SO4]]
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[[Category: surface glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:35:17 2008''
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Current revision

CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION

PDB ID 1cd8

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