3ueh

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[[Image:3ueh.jpg|left|200px]]
 
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==Crystal structure of human Survivin H80A mutant==
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The line below this paragraph, containing "STRUCTURE_3ueh", creates the "Structure Box" on the page.
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<StructureSection load='3ueh' size='340' side='right'caption='[[3ueh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ueh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UEH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ueh| PDB=3ueh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ueh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ueh OCA], [https://pdbe.org/3ueh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ueh RCSB], [https://www.ebi.ac.uk/pdbsum/3ueh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ueh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BIRC5_HUMAN BIRC5_HUMAN] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.<ref>PMID:10626797</ref> <ref>PMID:9859993</ref> <ref>PMID:12773388</ref> <ref>PMID:16322459</ref> <ref>PMID:16291752</ref> <ref>PMID:18591255</ref> <ref>PMID:20826784</ref> <ref>PMID:21536684</ref>
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===Crystal structure of human Survivin H80A mutant===
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==See Also==
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*[[Survivin|Survivin]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22357620 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22357620}}
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==About this Structure==
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[[3ueh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UEH OCA].
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==Reference==
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<ref group="xtra">PMID:022357620</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Higgins, J M.]]
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[[Category: Large Structures]]
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[[Category: Minor, W.]]
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[[Category: Higgins JM]]
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[[Category: Niedzialkowska, E.]]
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[[Category: Minor W]]
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[[Category: Porebski, P J.]]
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[[Category: Niedzialkowska E]]
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[[Category: Stukenberg, P T.]]
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[[Category: Porebski PJ]]
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[[Category: Wang, F.]]
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[[Category: Stukenberg PT]]
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[[Category: Bir domain]]
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[[Category: Wang F]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Chromosomal passenger complex]]
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[[Category: Mitosis]]
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[[Category: Zinc finger]]
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Current revision

Crystal structure of human Survivin H80A mutant

PDB ID 3ueh

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OCA

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