1cks

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[[Image:1cks.jpg|left|200px]]<br /><applet load="1cks" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1cks, resolution 2.1&Aring;" />
 
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'''HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL'''<br />
 
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==Overview==
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==HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL==
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The cell cycle regulatory protein CksHs2 binds to the catalytic subunit of, the cyclin-dependent kinases (Cdk's) and is essential for their biological, function. The crystal structure of the protein was determined at 2.1 A, resolution. The CksHs2 structure is an unexpected hexamer formed by the, symmetric assembly of three interlocked dimers into an unusual 12-stranded, beta barrel fold that may represent a prototype for this class of protein, structures. Sequence-conserved regions form the unusual beta strand, exchange between the subunits of the dimer, and the metal and anion, binding sites associated with the hexamer assembly. The two other, sequence-conserved regions line a 12 A diameter tunnel through the beta, barrel and form the six exposed, charged helix pairs. Six kinase subunits, can be modeled to bind the assembled hexamer without collision, and, therefore this CksHs2 hexamer may participate in cell cycle control by, acting as the hub for Cdk multimerization in vivo.
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<StructureSection load='1cks' size='340' side='right'caption='[[1cks]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cks]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cks OCA], [https://pdbe.org/1cks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cks RCSB], [https://www.ebi.ac.uk/pdbsum/1cks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cks ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CKS2_HUMAN CKS2_HUMAN] Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/1cks_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cks ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1CKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKS OCA].
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*[[Cyclin-dependent kinase regulatory subunit 3D structures|Cyclin-dependent kinase regulatory subunit 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control., Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA, Science. 1993 Oct 15;262(5132):387-95. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8211159 8211159]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arvai, A.S.]]
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[[Category: Arvai AS]]
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[[Category: Parge, H.E.]]
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[[Category: Parge HE]]
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[[Category: Tainer, J.A.]]
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[[Category: Tainer JA]]
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[[Category: SO4]]
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[[Category: cell division]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:36:14 2008''
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Current revision

HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL

PDB ID 1cks

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