2l0t

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[[Image:2l0t.png|left|200px]]
 
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==Solution structure of the complex of ubiquitin and the VHS domain of Stam2==
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The line below this paragraph, containing "STRUCTURE_2l0t", creates the "Structure Box" on the page.
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<StructureSection load='2l0t' size='340' side='right'caption='[[2l0t]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0t OCA], [https://pdbe.org/2l0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0t RCSB], [https://www.ebi.ac.uk/pdbsum/2l0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0t ProSAT]</span></td></tr>
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{{STRUCTURE_2l0t| PDB=2l0t | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the complex of ubiquitin and the VHS domain of Stam2===
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[https://www.uniprot.org/uniprot/STAM2_HUMAN STAM2_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
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The line below this paragraph, {{ABSTRACT_PUBMED_21121635}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 21121635 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21121635}}
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==About this Structure==
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[[2l0t]] is a 2 chain structure of [[Ubiquitin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0T OCA].
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==See Also==
==See Also==
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*[[Ubiquitin]]
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*[[3D structures of ubiquitin|3D structures of ubiquitin]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021121635</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hoeller, D.]]
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[[Category: Large Structures]]
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[[Category: Lancelin, J.]]
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[[Category: Hoeller D]]
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[[Category: Lange, A.]]
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[[Category: Lancelin J]]
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[[Category: Marcillat, O.]]
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[[Category: Lange A]]
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[[Category: Walker, O.]]
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[[Category: Marcillat O]]
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[[Category: Wienk, H.]]
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[[Category: Walker O]]
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[[Category: Endosome]]
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[[Category: Wienk H]]
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[[Category: Protein transport]]
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[[Category: Stam2]]
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[[Category: Transport]]
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[[Category: Ubiquitin]]
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[[Category: Vh]]
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Current revision

Solution structure of the complex of ubiquitin and the VHS domain of Stam2

PDB ID 2l0t

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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