3vf2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:26, 14 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3vf2.png|left|200px]]
 
-
<!--
+
==Crystal structure of the O-carbamoyltransferase TobZ M473I variant in complex with carbamoyl phosphate and ADP==
-
The line below this paragraph, containing "STRUCTURE_3vf2", creates the "Structure Box" on the page.
+
<StructureSection load='3vf2' size='340' side='right'caption='[[3vf2]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3vf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptoalloteichus_tenebrarius Streptoalloteichus tenebrarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VF2 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CP:PHOSPHORIC+ACID+MONO(FORMAMIDE)ESTER'>CP</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-
{{STRUCTURE_3vf2| PDB=3vf2 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vf2 OCA], [https://pdbe.org/3vf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vf2 RCSB], [https://www.ebi.ac.uk/pdbsum/3vf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vf2 ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal structure of the O-carbamoyltransferase TobZ M473I variant in complex with carbamoyl phosphate and ADP===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/TOBZ_STRSD TOBZ_STRSD] TobZ is involved in the biosynthesis of the 2-deoxystreptamine-containing aminoglycoside antibiotics such as nebramycin 5 and 6-O-carbamoylkanamycin. Catalyzes the hydrolysis of carbamoyl phosphate and its subsequent adenylation by ATP to yield O-carbamoyladenylate. Then it catalyzes the transfer of the carbamoyl moiety from O-carbamoyladenylate to the tobramycin 6-hydroxy group to yield nebramycin 5. It catalyzes the same reaction with kanamycin A. These reactions are considerably slower in the presence of deoxy-ATP.<ref>PMID:20936279</ref> <ref>PMID:22383337</ref>
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22383337}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 22383337 is the PubMed ID number.
+
</StructureSection>
-
-->
+
[[Category: Large Structures]]
-
{{ABSTRACT_PUBMED_22383337}}
+
-
 
+
-
==About this Structure==
+
-
[[3vf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptoalloteichus_tenebrarius Streptoalloteichus tenebrarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VF2 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022383337</ref><references group="xtra"/>
+
[[Category: Streptoalloteichus tenebrarius]]
[[Category: Streptoalloteichus tenebrarius]]
-
[[Category: Goerlich, S.]]
+
[[Category: Goerlich S]]
-
[[Category: Jaenecke, F.]]
+
[[Category: Jaenecke F]]
-
[[Category: Parthier, C.]]
+
[[Category: Parthier C]]
-
[[Category: Stubbs, M T.]]
+
[[Category: Stubbs MT]]
-
[[Category: Adenylation]]
+
-
[[Category: Antibiotic biosynthesis]]
+
-
[[Category: Enzyme evolution]]
+
-
[[Category: Structural enzymology]]
+
-
[[Category: Substrate assisted catalysis]]
+
-
[[Category: Substrate channeling]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of the O-carbamoyltransferase TobZ M473I variant in complex with carbamoyl phosphate and ADP

PDB ID 3vf2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3vf2"
Personal tools