This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3v2w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:45, 3 April 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3v2w.png|left|200px]]
 
-
<!--
+
==Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A==
-
The line below this paragraph, containing "STRUCTURE_3v2w", creates the "Structure Box" on the page.
+
<StructureSection load='3v2w' size='340' side='right'caption='[[3v2w]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V2W FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
{{STRUCTURE_3v2w| PDB=3v2w | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [https://pdbe.org/3v2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [https://www.ebi.ac.uk/pdbsum/3v2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2w ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/S1PR1_HUMAN S1PR1_HUMAN] G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.<ref>PMID:10982820</ref> <ref>PMID:11230698</ref> <ref>PMID:11583630</ref> <ref>PMID:11604399</ref> <ref>PMID:19286607</ref> <ref>PMID:22344443</ref> <ref>PMID:8626678</ref> <ref>PMID:9488656</ref> [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
-
===Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A===
+
==See Also==
-
 
+
*[[G protein-coupled receptor|G protein-coupled receptor]]
-
 
+
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
-
<!--
+
== References ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_22344443}}, adds the Publication Abstract to the page
+
<references/>
-
(as it appears on PubMed at http://www.pubmed.gov), where 22344443 is the PubMed ID number.
+
__TOC__
-
-->
+
</StructureSection>
-
{{ABSTRACT_PUBMED_22344443}}
+
[[Category: Escherichia virus T4]]
-
 
+
[[Category: Homo sapiens]]
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[3v2w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA].
+
[[Category: Cahalan SM]]
-
 
+
[[Category: Clemons B]]
-
==Reference==
+
[[Category: Desale H]]
-
<ref group="xtra">PMID:022344443</ref><references group="xtra"/>
+
[[Category: Griffith MT]]
-
[[Category: Homo sapiens, enterobacteria phage t4]]
+
[[Category: Han GW]]
-
[[Category: Lysozyme]]
+
[[Category: Hanson MA]]
-
[[Category: Cahalan, S M.]]
+
[[Category: Jo E]]
-
[[Category: Clemons, B.]]
+
[[Category: Kuhn P]]
-
[[Category: Desale, H.]]
+
[[Category: Reinhart G]]
-
[[Category: GPCR, GPCR Network.]]
+
[[Category: Rosen H]]
-
[[Category: Griffith, M T.]]
+
[[Category: Roth CB]]
-
[[Category: Han, G W.]]
+
[[Category: Sanna MG]]
-
[[Category: Hanson, M A.]]
+
[[Category: Schuerer SC]]
-
[[Category: Jo, E.]]
+
[[Category: Scott FL]]
-
[[Category: Kuhn, P.]]
+
[[Category: Stevens RC]]
-
[[Category: Reinhart, G.]]
+
-
[[Category: Rosen, H.]]
+
-
[[Category: Roth, C B.]]
+
-
[[Category: Sanna, M G.]]
+
-
[[Category: Schuerer, S C.]]
+
-
[[Category: Scott, F L.]]
+
-
[[Category: Stevens, R C.]]
+
-
[[Category: Autoimmunity]]
+
-
[[Category: Edg receptor]]
+
-
[[Category: G protein coupled receptor]]
+
-
[[Category: Gpcr]]
+
-
[[Category: Gpcr network]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Lipid receptor]]
+
-
[[Category: Membrane]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Multiple sclerosis]]
+
-
[[Category: Psi-biology]]
+
-
[[Category: Sphingosine]]
+
-
[[Category: Structural genomic]]
+

Current revision

Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A

PDB ID 3v2w

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3v2w"
Personal tools