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1dfb

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[[Image:1dfb.jpg|left|200px]]<br /><applet load="1dfb" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1dfb, resolution 2.7&Aring;" />
 
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'''STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I'''<br />
 
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==Overview==
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==STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I==
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The three-dimensional structure of a human monoclonal antibody (Fab), which binds specifically to a major epitope of the transmembrane protein, gp41 of the human immunodeficiency virus type 1, has been determined by, crystallographic methods to a resolution of 2.7 A. It has been previously, determined that this antibody recognizes the epitope SGKLICTTAVPWNAS, belongs to the subclass IgG1 (kappa), and exhibits antibody-dependent, cellular cytotoxicity. The quaternary structure of the Fab is in an, extended conformation with an elbow bend angle between the constant and, variable domains of 175 degrees. Structurally, four of the hypervariable, loops can be classified according to previously recognized canonical, structures. The third hypervariable loops of the heavy (H3) and light, chain (L3) are structurally distinct. Hypervariable loop H3, residues, 102H-109H, is unusually extended from the surface. The, complementarity-determining region forms a hydrophobic binding pocket that, is created primarily from hypervariable loops L3, H3, and H2.
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<StructureSection load='1dfb' size='340' side='right'caption='[[1dfb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dfb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DFB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dfb OCA], [https://pdbe.org/1dfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dfb RCSB], [https://www.ebi.ac.uk/pdbsum/1dfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dfb ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN] Defects in IGKC are the cause of immunoglobulin kappa light chain deficiency (IGKCD) [MIM:[https://omim.org/entry/614102 614102]. IGKCD is a disease characterized by the complete absence of immunoglobulin kappa chains.<ref>PMID:3931219</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/1dfb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dfb ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1DFB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFB OCA].
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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== References ==
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==Reference==
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<references/>
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Structure of a human monoclonal antibody Fab fragment against gp41 of human immunodeficiency virus type 1., He XM, Ruker F, Casale E, Carter DC, Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7154-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1496010 1496010]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Carter, D.C.]]
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[[Category: Homo sapiens]]
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[[Category: Casale, E.]]
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[[Category: Large Structures]]
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[[Category: He, X.M.]]
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[[Category: Carter DC]]
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[[Category: Rueker, F.]]
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[[Category: Casale E]]
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[[Category: immunoglobulin]]
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[[Category: He XM]]
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[[Category: Rueker F]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:39:35 2008''
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Current revision

STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I

PDB ID 1dfb

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