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4e08
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4e08 is ON HOLD Authors: Lin, J., Prahlad, J., Wilson, M.A. Description: Crystal structure of Drosophila melanogaster DJ-1beta) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Drosophila melanogaster DJ-1beta== | |
| + | <StructureSection load='4e08' size='340' side='right'caption='[[4e08]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4e08]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E08 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e08 OCA], [https://pdbe.org/4e08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e08 RCSB], [https://www.ebi.ac.uk/pdbsum/4e08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e08 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DJ1B_DROME DJ1B_DROME] Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor (PubMed:16139214, PubMed:16203113, PubMed:16894167, PubMed:20457924). Does not play a role in methylglyoxal detoxification (PubMed:27903648). Plays a role in mitochondrial function together with Pink1 (PubMed:20457924). In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN-phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels (PubMed:30540251).<ref>PMID:16139214</ref> <ref>PMID:16203113</ref> <ref>PMID:16894167</ref> <ref>PMID:20457924</ref> <ref>PMID:27903648</ref> <ref>PMID:30540251</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Protein DJ-1|Protein DJ-1]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Drosophila melanogaster]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lin J]] | ||
| + | [[Category: Prahlad J]] | ||
| + | [[Category: Wilson MA]] | ||
Current revision
Crystal structure of Drosophila melanogaster DJ-1beta
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