3zxu

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[[Image:3zxu.jpg|left|200px]]
 
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==Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast==
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The line below this paragraph, containing "STRUCTURE_3zxu", creates the "Structure Box" on the page.
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<StructureSection load='3zxu' size='340' side='right'caption='[[3zxu]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3zxu| PDB=3zxu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxu OCA], [https://pdbe.org/3zxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxu RCSB], [https://www.ebi.ac.uk/pdbsum/3zxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CENPO_KLULA CENPO_KLULA] Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis (By similarity). Component of the inner kinetochore COMA subcomplex, which connects centromere-associated proteins and the outer kinetochore (PubMed:29046335). COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity).[UniProtKB:Q06675]<ref>PMID:29046335</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The proteins Ctf19, Okp1, Mcm21 and Ame1 are the components of COMA, a subassembly of budding-yeast kinetochores. We have determined the crystal structure of a conserved COMA subcomplex-the Ctf19-Mcm21 heterodimer-from Kluyveromyces lactis. Both proteins contain 'double-RWD' domains, which together form a Y-shaped framework with flexible N-terminal extensions. The kinetochore proteins Csm1, Spc24 and Spc25 have related single RWD domains, and Ctf19 and Mcm21 associate with pseudo-twofold symmetry analogous to that in the Csm1 homodimer and the Spc24-Spc25 heterodimer. The double-RWD domain core of the Ctf19-Mcm21 heterodimer is sufficient for association with Okp1-Ame1; the less conserved N-terminal regions may interact with components of a more extensive 'CTF19 complex'. Our structure shows the RWD domain to be a recurring module of kinetochore architecture that may be present in other kinetochore substructures. Like many eukaryotic molecular machines, kinetochores may have evolved from simpler assemblies by multiplication of a few ancestral modules.
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===Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast===
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RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure.,Schmitzberger F, Harrison SC EMBO Rep. 2012 Mar 1;13(3):216-22. doi: 10.1038/embor.2012.1. PMID:22322944<ref>PMID:22322944</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zxu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22322944 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22322944}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Kluyveromyces lactis NRRL Y-1140]]
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[[3zxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXU OCA].
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[[Category: Large Structures]]
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[[Category: Harrison SC]]
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==Reference==
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[[Category: Schmitzberger F]]
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<ref group="xtra">PMID:022322944</ref><references group="xtra"/>
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[[Category: Kluyveromyces lactis]]
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[[Category: Harrison, S C.]]
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[[Category: Schmitzberger, F.]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Coma complex]]
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[[Category: Protein complex]]
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Current revision

Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast

PDB ID 3zxu

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