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2lee

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[[Image:2lee.jpg|left|200px]]
 
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==Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene==
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The line below this paragraph, containing "STRUCTURE_2lee", creates the "Structure Box" on the page.
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<StructureSection load='2lee' size='340' side='right'caption='[[2lee]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lee]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LEE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lee OCA], [https://pdbe.org/2lee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lee RCSB], [https://www.ebi.ac.uk/pdbsum/2lee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lee ProSAT]</span></td></tr>
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{{STRUCTURE_2lee| PDB=2lee | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A multidimensional heteronuclear NMR study has demonstrated that a guanine-rich DNA oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the presence of K(+), NH(4)(+), and Na(+) ions. A monomeric G-quadruplex formed in K(+) ion containing solution exhibits three G-quartets and flexible propeller-type loops. The 3D structure with three single nucleotide loops represents a missing element in structures of parallel G-quadruplexes. The structural features together with the high temperature stability are suggestive of the specific biological role of G-quadruplex formation within the intron of the N-myc gene. An increase in K(+) ion and oligonucleotide concentrations resulted in transformation of the monomeric G-quadruplex into a dimeric form. The dimeric G-quadruplex exhibits six stacked G-quartets, parallel strand orientations, and propeller-type loops. A link between the third and the fourth G-quartets consists of two adenine residues that are flipped out to facilitate consecutive stacking of six G-quartets.
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===Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene===
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Unique Structural Features of Interconverting Monomeric and Dimeric G-Quadruplexes Adopted by a Sequence from the Intron of the N-myc Gene.,Trajkovski M, Webba da Silva M, Plavec J J Am Chem Soc. 2012 Mar 7;134(9):4132-41. Epub 2012 Feb 22. PMID:22303871<ref>PMID:22303871</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22303871}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2lee" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22303871 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22303871}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2lee]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEE OCA].
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[[Category: Plavec J]]
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[[Category: Trajkovski M]]
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==Reference==
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[[Category: Webba da Silva M]]
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<ref group="xtra">PMID:022303871</ref><references group="xtra"/>
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[[Category: Plavec, J.]]
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[[Category: Silva, M Webba da.]]
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[[Category: Trajkovski, M.]]
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[[Category: Dna]]
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[[Category: G-quadruplex]]
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[[Category: Intron]]
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[[Category: Monomer-dimer equilibrium]]
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[[Category: N-myc]]
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Current revision

Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene

PDB ID 2lee

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