3tp2

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[[Image:3tp2.jpg|left|200px]]
 
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==Crystal Structure of the Splicing Factor Cwc2 from yeast==
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The line below this paragraph, containing "STRUCTURE_3tp2", creates the "Structure Box" on the page.
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<StructureSection load='3tp2' size='340' side='right'caption='[[3tp2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tp2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TP2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3tp2| PDB=3tp2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tp2 OCA], [https://pdbe.org/3tp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tp2 RCSB], [https://www.ebi.ac.uk/pdbsum/3tp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tp2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CWC2_YEAST CWC2_YEAST] Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the "nineteen complex" NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Binds also to U1, U4, U5 and U6 snRNAs and to pre-mRNAs, in vitro. Is not required for the Prp2-mediated remodeling of the activated spliceosome.<ref>PMID:19435883</ref> <ref>PMID:22246180</ref>
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===Crystal Structure of the Splicing Factor Cwc2 from yeast===
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==See Also==
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*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3tp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TP2 OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Schmitzova, J.]]
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[[Category: Schmitzova J]]
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[[Category: Ccch zinc finger]]
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[[Category: Rna scaffold]]
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[[Category: Rrm domain]]
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[[Category: Splicing]]
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[[Category: Torus domain]]
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Current revision

Crystal Structure of the Splicing Factor Cwc2 from yeast

PDB ID 3tp2

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OCA

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