3twi

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[[Image:3twi.jpg|left|200px]]
 
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==Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores==
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The line below this paragraph, containing "STRUCTURE_3twi", creates the "Structure Box" on the page.
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<StructureSection load='3twi' size='340' side='right'caption='[[3twi]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_3twi| PDB=3twi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [https://pdbe.org/3twi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [https://www.ebi.ac.uk/pdbsum/3twi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q81JD7_BACAN Q81JD7_BACAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Variable lymphocyte receptors (VLRs) are the adaptive immune receptors of jawless fish, which evolved adaptive immunity independent of other vertebrates. In lieu of the immunoglobulin fold-based T and B cell receptors, lymphocyte-like cells of jawless fish express VLRs (VLRA, VLRB, or VLRC) composed of leucine-rich repeats and are similar to toll-like receptors (TLRs) in structure, but antibodies (VLRB) and T cell receptors (VLRA and VLRC) in function. Here, we present the structural and biochemical characterization of VLR4, a VLRB, in complex with BclA, the immunodominant glycoprotein of Bacillus anthracis spores. Using a combination of crystallography, mutagenesis, and binding studies, we delineate the mode of antigen recognition and binding between VLR4 and BclA, examine commonalities in VLRB recognition of antigens, and demonstrate the potential of VLR4 as a diagnostic tool for the identification of B. anthracis spores.
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===Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores===
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Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores.,Kirchdoerfer RN, Herrin BR, Han BW, Turnbough CL Jr, Cooper MD, Wilson IA Structure. 2012 Mar 7;20(3):479-86. PMID:22405006<ref>PMID:22405006</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3twi" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3twi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA].
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Large Structures]]
[[Category: Petromyzon marinus]]
[[Category: Petromyzon marinus]]
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[[Category: Cooper, M D.]]
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[[Category: Cooper MD]]
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[[Category: Han, B W.]]
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[[Category: Han BW]]
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[[Category: Herrin, B R.]]
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[[Category: Herrin BR]]
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[[Category: Kirchdoerfer, R N.]]
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[[Category: Kirchdoerfer RN]]
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[[Category: Turnbough, C L.]]
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[[Category: Turnbough Jr CL]]
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[[Category: Wilson, I A.]]
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[[Category: Wilson IA]]
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[[Category: Antigen-binding]]
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[[Category: Immune system]]
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[[Category: Leucine-rich repeat]]
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[[Category: Secreted]]
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Current revision

Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores

PDB ID 3twi

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