Sarcosine oxidase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: <!-- Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. Or use the four-green-boxes-button to insert scrollable text adjacent to a Jmol applet. Che...)
Current revision (07:50, 15 March 2022) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
<!--
+
<StructureSection load='3ad8' size='350' side='right' scene='' caption='Heterotetramer of sarcosine oxidase containing FAD, FMN and NAD showing α subunit (grey), β subunit (green), γ subunit (pink) and δ subunit (yellow). Complex with pyrrole-2-carboxylate, sulfate and Zn+2 ions (grey) [[3ad8]]'>
-
Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+
-
Or use the four-green-boxes-button to insert scrollable text adjacent
+
-
to a Jmol applet. Check out the other buttons as well!
+
-
-->
+
-
'''Sarcosine oxidase''' (SOX) catalyzes the demethylation of sarcosine+O2+H4-tetrahydrofolate to produce glycine, hydrogen peroxide and 5, 10-methylene-tetrahydrofolate. Sarcosine metabolism can be the source of carbon and energy for many microorganisms. SOXs are found as monomers, heterodirmers and heterotetramers. Monomeric SOX uses FAD as cofactor. Heterotetrameric SOX uses FAD and FMN as cofactors.
+
 +
'''Sarcosine oxidase''' (SOX) catalyzes the demethylation of sarcosine+O2+H4-tetrahydrofolate to produce glycine, hydrogen peroxide and 5, 10-methylene-tetrahydrofolate. Sarcosine metabolism can be the source of carbon and energy for many microorganisms. SOXs are found as monomers, heterodirmers and heterotetramers<ref>PMID:24185971</ref>. Monomeric SOX uses FAD as cofactor. Heterotetrameric SOX uses FAD and FMN as cofactors.
 +
</StructureSection>
==3D structures of sarcosine oxidase==
==3D structures of sarcosine oxidase==
-
'''SOX monomer'''
+
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
[[1el5]], [[1el7]], [[1el8]], [[1eli]], [[2gf3]] – BaSOX + inhibitor – ''Bacillus''<br />
+
*Monomeric sarcosine oxidase
-
[[1l9c]], [[1l9d]], [[1l9e]], [[3bhf]], [[3bhk]], [[3m0o]], [[3m12]], [[3m13]] – BaSOX (mutant)<br />
+
-
[[2a89]], [[2gb0]], [[1zov]] - BaSOX
+
-
'''SOX heterotetramer'''
+
**[[1el5]], [[1el7]], [[1el8]], [[1el9]], [[1eli]], [[2gf3]] – BaSOX + inhibitor – ''Bacillus''<br />
 +
**[[1l9c]], [[1l9d]], [[1l9e]], [[3bhf]], [[3bhk]], [[3m0o]], [[3m12]], [[3m13]] – BaSOX (mutant)<br />
 +
**[[2a89]], [[2gb0]], [[1zov]], [[3qsm]], [[3qss]] - BaSOX<br />
 +
**[[3qse]] – BaSOX + arcosine<br />
 +
**[[1y56]] – SOX + protein – ''Pyrococcus horikoshii''<br />
 +
**[[7exs]] – SOX (mutant) – ''Thermomicrobium roseum''<br />
-
[[1vrg]] – CoSOX + folinic acid – ''Corynebacterium''<br />
+
*Sarcosine oxidase heterotetramer
-
[[3ad7]] – CoSOX + methylthio acetate<br />
+
 
-
[[3ad8]] – CoSOX + pyrrole 2-carboxylate<br />
+
**[[1vrq]] – CoSOX + folinic acid – ''Corynebacterium''<br />
-
[[3ada]] – CoSOX + sulfite<br />
+
**[[3ad7]] – CoSOX + methylthio acetate<br />
-
[[1x31]], [[3ad9]] – CoSOX<br />
+
**[[3ad8]] – CoSOX + pyrrole 2-carboxylate<br />
-
[[2gag]], [[2gah]] – SOX + furoic acid – ''Stenotrophomonas maltophilia''
+
**[[3ada]] – CoSOX + sulfite<br />
 +
**[[1x31]], [[3ad9]] – CoSOX<br />
 +
**[[2gag]], [[2gah]] – SOX + furoic acid – ''Stenotrophomonas maltophilia''
 +
}}
 +
== References ==
 +
<references/>
 +
[[Category:Topic Page]]

Current revision

Heterotetramer of sarcosine oxidase containing FAD, FMN and NAD showing α subunit (grey), β subunit (green), γ subunit (pink) and δ subunit (yellow). Complex with pyrrole-2-carboxylate, sulfate and Zn+2 ions (grey) 3ad8

Drag the structure with the mouse to rotate

3D structures of sarcosine oxidase

Updated on 15-March-2022

References

  1. ↑ Suzuki H. Sarcosine oxidase: structure, function, and the application to creatinine determination. Amino Acids. 1994 Feb;7(1):27-43. doi: 10.1007/BF00808444. PMID:24185971 doi:http://dx.doi.org/10.1007/BF00808444

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Sarcosine_oxidase"
Personal tools