3hws

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[[Image:3hws.png|left|200px]]
 
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==Crystal structure of nucleotide-bound hexameric ClpX==
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The line below this paragraph, containing "STRUCTURE_3hws", creates the "Structure Box" on the page.
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<StructureSection load='3hws' size='340' side='right'caption='[[3hws]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hws]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HWS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3hws| PDB=3hws | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hws OCA], [https://pdbe.org/3hws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hws RCSB], [https://www.ebi.ac.uk/pdbsum/3hws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hws ProSAT]</span></td></tr>
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</table>
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===Crystal structure of nucleotide-bound hexameric ClpX===
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== Function ==
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[https://www.uniprot.org/uniprot/CLPX_ECOLI CLPX_ECOLI] ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. It may bind to the lambda O substrate protein and present it to the ClpP protease in a form that can be recognized and readily hydrolyzed by ClpP. Can perform chaperone functions in the absence of ClpP.[HAMAP-Rule:MF_00175]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19914167 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/3hws_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19914167}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3hws]] is a 6 chain structure of [[ClpX]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HWS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hws ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[ClpX]]
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*[[Clp protease 3D structures|Clp protease 3D structures]]
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*[[Molecular Playground/Hexameric ClpX]]
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Escherichia coli K-12]]
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<ref group="xtra">PMID:019914167</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Escherichia coli]]
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[[Category: Baker TA]]
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[[Category: Baker, T A.]]
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[[Category: Glynn SE]]
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[[Category: Glynn, S E.]]
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[[Category: Martin A]]
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[[Category: Martin, A.]]
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[[Category: Sauer RT]]
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[[Category: Sauer, R T.]]
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[[Category: Aaa+ molecular machine]]
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[[Category: Asymmetric]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Clpxp]]
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[[Category: Hexamer]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Motor protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Stress response]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of nucleotide-bound hexameric ClpX

PDB ID 3hws

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