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| - | [[Image:3v79.png|left|200px]] | |
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| - | <!--
| + | ==Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence== |
| - | The line below this paragraph, containing "STRUCTURE_3v79", creates the "Structure Box" on the page.
| + | <StructureSection load='3v79' size='340' side='right'caption='[[3v79]], [[Resolution|resolution]] 3.85Å' scene=''> |
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet)
| + | == Structural highlights == |
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| + | <table><tr><td colspan='2'>[[3v79]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V79 FirstGlance]. <br> |
| - | or leave the SCENE parameter empty for the default display.
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.85Å</td></tr> |
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| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v79 OCA], [https://pdbe.org/3v79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v79 RCSB], [https://www.ebi.ac.uk/pdbsum/3v79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v79 ProSAT]</span></td></tr> |
| - | {{STRUCTURE_3v79| PDB=3v79 | SCENE= }}
| + | </table> |
| - | | + | == Function == |
| - | ===Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence===
| + | [https://www.uniprot.org/uniprot/MAML1_HUMAN MAML1_HUMAN] Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.<ref>PMID:11101851</ref> <ref>PMID:11390662</ref> <ref>PMID:12050117</ref> <ref>PMID:15546612</ref> <ref>PMID:17317671</ref> |
| - | | + | == References == |
| - | | + | <references/> |
| - | <!-- | + | __TOC__ |
| - | The line below this paragraph, {{ABSTRACT_PUBMED_22325781}}, adds the Publication Abstract to the page
| + | </StructureSection> |
| - | (as it appears on PubMed at http://www.pubmed.gov), where 22325781 is the PubMed ID number.
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| - | -->
| + | |
| - | {{ABSTRACT_PUBMED_22325781}}
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| - | | + | |
| - | ==About this Structure== | + | |
| - | [[3v79]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V79 OCA]. | + | |
| - | | + | |
| - | ==Reference== | + | |
| - | <ref group="xtra">PMID:022325781</ref><references group="xtra"/> | + | |
| | [[Category: Homo sapiens]] | | [[Category: Homo sapiens]] |
| - | [[Category: Blacklow, S.]] | + | [[Category: Large Structures]] |
| - | [[Category: Nam, Y.]] | + | [[Category: Blacklow S]] |
| - | [[Category: Sliz, P.]] | + | [[Category: Nam Y]] |
| - | [[Category: Ankyrin]] | + | [[Category: Sliz P]] |
| - | [[Category: Beta-trefoil]]
| + | |
| - | [[Category: Dna binding]]
| + | |
| - | [[Category: Transcription activation]]
| + | |
| - | [[Category: Transcription-dna complex]]
| + | |
| Structural highlights
Function
MAML1_HUMAN Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.[1] [2] [3] [4] [5]
References
- ↑ Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet. 2000 Dec;26(4):484-9. PMID:11101851 doi:10.1038/82644
- ↑ Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K. A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. Mol Cell Biol. 2001 Jul;21(13):4337-46. PMID:11390662 doi:10.1128/MCB.21.13.4337-4346.2001
- ↑ Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev. 2002 Jun 1;16(11):1397-411. PMID:12050117 doi:10.1101/gad.991602
- ↑ Fryer CJ, White JB, Jones KA. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell. 2004 Nov 19;16(4):509-20. PMID:15546612 doi:S1097276504006409
- ↑ Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V. The notch regulator MAML1 interacts with p53 and functions as a coactivator. J Biol Chem. 2007 Apr 20;282(16):11969-81. Epub 2007 Feb 22. PMID:17317671 doi:M608974200
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