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3qwv

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[[Image:3qwv.png|left|200px]]
 
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==Crystal structure of histone lysine methyltransferase SmyD2 in complex with the cofactor product AdoHcy==
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The line below this paragraph, containing "STRUCTURE_3qwv", creates the "Structure Box" on the page.
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<StructureSection load='3qwv' size='340' side='right'caption='[[3qwv]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qwv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3qwv| PDB=3qwv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwv OCA], [https://pdbe.org/3qwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwv RCSB], [https://www.ebi.ac.uk/pdbsum/3qwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwv ProSAT]</span></td></tr>
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</table>
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===Crystal structure of histone lysine methyltransferase SmyD2 in complex with the cofactor product AdoHcy===
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== Function ==
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[https://www.uniprot.org/uniprot/SMYD2_MOUSE SMYD2_MOUSE] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.<ref>PMID:16805913</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21738746 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_21738746}}
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==About this Structure==
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[[3qwv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWV OCA].
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==Reference==
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<ref group="xtra">PMID:021738746</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Brunzelle, J.]]
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[[Category: Brunzelle J]]
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[[Category: Jiang, Y.]]
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[[Category: Jiang Y]]
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[[Category: Sirinupong, N.]]
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[[Category: Sirinupong N]]
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[[Category: Yang, Z.]]
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[[Category: Yang Z]]
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[[Category: Hsp90]]
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[[Category: Methyltransferase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of histone lysine methyltransferase SmyD2 in complex with the cofactor product AdoHcy

PDB ID 3qwv

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