3p98

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[[Image:3p98.png|left|200px]]
 
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==The crystal structure of the extended spectrum beta-lactamase TEM-72 reveals inhibition by citrate==
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The line below this paragraph, containing "STRUCTURE_3p98", creates the "Structure Box" on the page.
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<StructureSection load='3p98' size='340' side='right'caption='[[3p98]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3p98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Morganella_morganii Morganella morganii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P98 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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{{STRUCTURE_3p98| PDB=3p98 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p98 OCA], [https://pdbe.org/3p98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p98 RCSB], [https://www.ebi.ac.uk/pdbsum/3p98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p98 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9R429_MORMO Q9R429_MORMO]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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TEM-72, a class A beta-lactamase identified in isolates of Enterobacteriaceae, is a quadruple mutant of TEM-1 (Q39K, M182T, G238S and E240K) and shows extended-spectrum beta-lactamase (ESBL) properties arising from the G238S and E240K substitutions. Although many structures of TEM variants have been published, they do not include an enzyme with the simultaneous presence of both of the ESBL-conferring G238S and E240K substitutions. Furthermore, the structure shows the presence of a citrate anion bound to the TEM-72 active site, where it interacts with all of the conserved residues of class A beta-lactamases. The present structure supports the use of polycarboxylates as a scaffold for the design of broad-spectrum inhibitors of serine beta-lactamases.
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===The crystal structure of the extended spectrum beta-lactamase TEM-72 reveals inhibition by citrate===
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Structure of the extended-spectrum beta-lactamase TEM-72 inhibited by citrate.,Docquier JD, Benvenuti M, Calderone V, Rossolini GM, Mangani S Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt, 3):303-6. Epub 2011 Feb 18. PMID:21393831<ref>PMID:21393831</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3p98" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21393831 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21393831}}
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==About this Structure==
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[[3p98]] is a 2 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Morganella_morganii Morganella morganii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P98 OCA].
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==See Also==
==See Also==
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*[[Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021393831</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Morganella morganii]]
[[Category: Morganella morganii]]
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[[Category: Benvenuti, M.]]
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[[Category: Benvenuti M]]
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[[Category: Calderone, V.]]
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[[Category: Calderone V]]
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[[Category: Docquier, J D.]]
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[[Category: Docquier JD]]
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[[Category: Mangani, S.]]
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[[Category: Mangani S]]
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[[Category: Rossolini, G M.]]
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[[Category: Rossolini GM]]
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[[Category: Aba-sandwich]]
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[[Category: Beta-lactamase]]
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[[Category: Hydrolase]]
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Current revision

The crystal structure of the extended spectrum beta-lactamase TEM-72 reveals inhibition by citrate

PDB ID 3p98

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