3qbv

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[[Image:3qbv.png|left|200px]]
 
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==Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin==
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The line below this paragraph, containing "STRUCTURE_3qbv", creates the "Structure Box" on the page.
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<StructureSection load='3qbv' size='340' side='right'caption='[[3qbv]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qbv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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{{STRUCTURE_3qbv| PDB=3qbv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbv OCA], [https://pdbe.org/3qbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbv RCSB], [https://www.ebi.ac.uk/pdbsum/3qbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
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===Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin===
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Intersectin|Intersectin]]
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== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 22403064 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_22403064}}
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==About this Structure==
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[[3qbv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBV OCA].
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==Reference==
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<ref group="xtra">PMID:022403064</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kapp, G T.]]
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[[Category: Large Structures]]
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[[Category: Kortemme, T.]]
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[[Category: Kapp GT]]
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[[Category: Lim, W A.]]
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[[Category: Kortemme T]]
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[[Category: Remenyi, A.]]
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[[Category: Lim WA]]
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[[Category: Cell junction]]
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[[Category: Remenyi A]]
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[[Category: Cell membrane]]
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[[Category: Cell projection]]
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[[Category: Computationally designed]]
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[[Category: Endocytosis]]
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[[Category: Gtp-binding]]
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[[Category: Gtpase]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Methylation]]
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[[Category: Nucleotide exchange]]
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[[Category: Nucleotide-binding]]
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[[Category: Orthogonal interaction]]
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[[Category: Phosphoprotein]]
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[[Category: Prenylation]]
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[[Category: Protein binding-signaling protein complex]]
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[[Category: Sh3 domain]]
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[[Category: Synapse]]
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[[Category: Synaptosome]]
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Current revision

Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin

PDB ID 3qbv

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