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3p11

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[[Image:3p11.png|left|200px]]
 
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==anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region==
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The line below this paragraph, containing "STRUCTURE_3p11", creates the "Structure Box" on the page.
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<StructureSection load='3p11' size='340' side='right'caption='[[3p11]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3p11]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P11 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3p11| PDB=3p11 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p11 OCA], [https://pdbe.org/3p11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p11 RCSB], [https://www.ebi.ac.uk/pdbsum/3p11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p11 ProSAT]</span></td></tr>
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</table>
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===anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region===
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== Disease ==
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[https://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN] Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:[https://omim.org/entry/607598 607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.<ref>PMID:17701904</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN] Binds and is activated by neuregulins and NTAK.<ref>PMID:15358134</ref>
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The line below this paragraph, {{ABSTRACT_PUBMED_22014573}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22014573 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22014573}}
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</StructureSection>
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==About this Structure==
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[[3p11]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P11 OCA].
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==Reference==
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<ref group="xtra">PMID:022014573</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Large Structures]]
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[[Category: Eigenbrot, C.]]
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[[Category: Eigenbrot C]]
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[[Category: Shia, S.]]
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[[Category: Shia S]]
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[[Category: Antigens her3]]
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[[Category: Beta-sandwich]]
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[[Category: Immune system]]
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Current revision

anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region

PDB ID 3p11

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