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3q7d

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[[Image:3q7d.png|left|200px]]
 
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==Structure of (R)-naproxen bound to mCOX-2.==
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The line below this paragraph, containing "STRUCTURE_3q7d", creates the "Structure Box" on the page.
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<StructureSection load='3q7d' size='340' side='right'caption='[[3q7d]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q7d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NPX:(2R)-2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOIC+ACID'>NPX</scene></td></tr>
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{{STRUCTURE_3q7d| PDB=3q7d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7d OCA], [https://pdbe.org/3q7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7d RCSB], [https://www.ebi.ac.uk/pdbsum/3q7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid and the endocannabinoids 2-arachidonoylglycerol and arachidonoylethanolamide. Evaluation of a series of COX-2 inhibitors revealed that many weak competitive inhibitors of arachidonic acid oxygenation are potent inhibitors of endocannabinoid oxygenation. (R) enantiomers of ibuprofen, naproxen and flurbiprofen, which are considered to be inactive as COX-2 inhibitors, are potent 'substrate-selective inhibitors' of endocannabinoid oxygenation. Crystal structures of the COX-2-(R)-naproxen and COX-2-(R)-flurbiprofen complexes verified this unexpected binding and defined the orientation of the (R) enantiomers relative to (S) enantiomers. (R)-Profens selectively inhibited endocannabinoid oxygenation by lipopolysaccharide-stimulated dorsal root ganglion (DRG) cells. Substrate-selective inhibition provides new tools for investigating the role of COX-2 in endocannabinoid oxygenation and a possible explanation for the ability of (R)-profens to maintain endocannabinoid tone in models of neuropathic pain.
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===Structure of (R)-naproxen bound to mCOX-2.===
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(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.,Duggan KC, Hermanson DJ, Musee J, Prusakiewicz JJ, Scheib JL, Carter BD, Banerjee S, Oates JA, Marnett LJ Nat Chem Biol. 2011 Nov;7(11):803-9. PMID:22053353<ref>PMID:22053353</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3q7d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7D OCA].
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<div class="pdbe-citations 3q7d" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Cyclooxygenase]]
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*[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021931302</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Prostaglandin-endoperoxide synthase]]
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[[Category: Banerjee S]]
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[[Category: Banerjee, S.]]
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[[Category: Carter BD]]
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[[Category: Carter, B D.]]
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[[Category: Duggan KC]]
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[[Category: Duggan, K C.]]
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[[Category: Hermanson DJ]]
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[[Category: Hermanson, D J.]]
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[[Category: Marnett LJ]]
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[[Category: Marnett, L J.]]
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[[Category: Musee J]]
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[[Category: Musee, J.]]
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[[Category: Prusakiewicz JJ]]
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[[Category: Prusakiewicz, J J.]]
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[[Category: Scheib J]]
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[[Category: Scheib, J.]]
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[[Category: Cyclooxygenase-2]]
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[[Category: Naproxen]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Prostaglandin h2 synthase]]
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Current revision

Structure of (R)-naproxen bound to mCOX-2.

PDB ID 3q7d

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